Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis
The objective: to study the frequency and nature of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with and without concurrent diabetes mellitus.Subjects and methods. 396 patients with pulmonary tuberculosis were examined: 203 patients who had diabetes were inclu...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2020-03-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1391 |
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| author | O. G. Komissarova R. Yu. Аbdullaev S. V. Aleshina |
| author_facet | O. G. Komissarova R. Yu. Аbdullaev S. V. Aleshina |
| author_sort | O. G. Komissarova |
| collection | DOAJ |
| description | The objective: to study the frequency and nature of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with and without concurrent diabetes mellitus.Subjects and methods. 396 patients with pulmonary tuberculosis were examined: 203 patients who had diabetes were included in the TB + diabetes group; the TB group consisted of 193 patients with pulmonary tuberculosis without diabetes.Results. The incidence of adverse events caused by anti-tuberculosis drugs was analyzed and compared in both groups. Thus, in the TB+diabetes group adverse events developed in 146/203 (71.9%) patients and in 62/193 (32.1%) patients in the TB group ( p < 0.01). Hepatotoxic reactions prevailed in both groups, but in the TB + diabetes group, they were statistically significantly more frequent versus the TB group (55.2 and 27.4%, respectively; p < 0.01). Also, allergic reactions (20.7 and 6.2%, respectively; p < 0.01) and neurotoxic events (13.3 and 5.1%, respectively; p < 0.01) were statistically significantly more frequent in the TB + diabetes group compared to the TB group. |
| format | Article |
| id | doaj-art-e73eabc9a45a45548312df94bfa0468f |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2020-03-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-e73eabc9a45a45548312df94bfa0468f2025-08-20T01:47:52ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062020-03-01982101410.21292/2075-1230-2020-98-2-10-141391Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitisO. G. Komissarova0R. Yu. Аbdullaev1S. V. Aleshina2Central Tuberculosis Research Institute, Pirogov Russian National Research Medical UniversityCentral Tuberculosis Research InstituteCentral Tuberculosis Research InstituteThe objective: to study the frequency and nature of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with and without concurrent diabetes mellitus.Subjects and methods. 396 patients with pulmonary tuberculosis were examined: 203 patients who had diabetes were included in the TB + diabetes group; the TB group consisted of 193 patients with pulmonary tuberculosis without diabetes.Results. The incidence of adverse events caused by anti-tuberculosis drugs was analyzed and compared in both groups. Thus, in the TB+diabetes group adverse events developed in 146/203 (71.9%) patients and in 62/193 (32.1%) patients in the TB group ( p < 0.01). Hepatotoxic reactions prevailed in both groups, but in the TB + diabetes group, they were statistically significantly more frequent versus the TB group (55.2 and 27.4%, respectively; p < 0.01). Also, allergic reactions (20.7 and 6.2%, respectively; p < 0.01) and neurotoxic events (13.3 and 5.1%, respectively; p < 0.01) were statistically significantly more frequent in the TB + diabetes group compared to the TB group.https://www.tibl-journal.com/jour/article/view/1391tuberculosisdiabetes myelitisadverse events caused by anti-tuberculosis drugs |
| spellingShingle | O. G. Komissarova R. Yu. Аbdullaev S. V. Aleshina Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis Туберкулез и болезни лёгких tuberculosis diabetes myelitis adverse events caused by anti-tuberculosis drugs |
| title | Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis |
| title_full | Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis |
| title_fullStr | Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis |
| title_full_unstemmed | Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis |
| title_short | Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis |
| title_sort | frequency and characteristics of adverse events caused by anti tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis |
| topic | tuberculosis diabetes myelitis adverse events caused by anti-tuberculosis drugs |
| url | https://www.tibl-journal.com/jour/article/view/1391 |
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