Frequency and characteristics of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with diabetes myelitis
The objective: to study the frequency and nature of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with and without concurrent diabetes mellitus.Subjects and methods. 396 patients with pulmonary tuberculosis were examined: 203 patients who had diabetes were inclu...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
New Terra Publishing House
2020-03-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1391 |
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| Summary: | The objective: to study the frequency and nature of adverse events caused by anti-tuberculosis drugs in pulmonary tuberculosis patients with and without concurrent diabetes mellitus.Subjects and methods. 396 patients with pulmonary tuberculosis were examined: 203 patients who had diabetes were included in the TB + diabetes group; the TB group consisted of 193 patients with pulmonary tuberculosis without diabetes.Results. The incidence of adverse events caused by anti-tuberculosis drugs was analyzed and compared in both groups. Thus, in the TB+diabetes group adverse events developed in 146/203 (71.9%) patients and in 62/193 (32.1%) patients in the TB group ( p < 0.01). Hepatotoxic reactions prevailed in both groups, but in the TB + diabetes group, they were statistically significantly more frequent versus the TB group (55.2 and 27.4%, respectively; p < 0.01). Also, allergic reactions (20.7 and 6.2%, respectively; p < 0.01) and neurotoxic events (13.3 and 5.1%, respectively; p < 0.01) were statistically significantly more frequent in the TB + diabetes group compared to the TB group. |
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| ISSN: | 2075-1230 2542-1506 |