Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover
It is unclear which vitamin D status is optimal for bone health. In this study, we aimed to assess cutoffs of 25-hydroxyvitamin D (25OHD) derived by the literature (20, 25, or 30 ng/mL) in relation to bone turnover and bone mineral density (BMD). Serum 25OHD, PTH, osteocalcin, bone alkaline phosphat...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2014/487463 |
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| _version_ | 1850167573029584896 |
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| author | Nicola Napoli Rocky Strollo Delia Sprini Ernesto Maddaloni Giovam Battista Rini Enrico Carmina |
| author_facet | Nicola Napoli Rocky Strollo Delia Sprini Ernesto Maddaloni Giovam Battista Rini Enrico Carmina |
| author_sort | Nicola Napoli |
| collection | DOAJ |
| description | It is unclear which vitamin D status is optimal for bone health. In this study, we aimed to assess cutoffs of 25-hydroxyvitamin D (25OHD) derived by the literature (20, 25, or 30 ng/mL) in relation to bone turnover and bone mineral density (BMD). Serum 25OHD, PTH, osteocalcin, bone alkaline phosphatase, and C-telopeptide were measured in 274 consecutive postmenopausal women. BMD of the lumbar spine (L1–L4) and of femoral neck were also evaluated. 50 patients had normal BMD, while 124 had osteopenia and 100 had osteoporosis. 37.6%, 56.2%, and 70.8% subjects had serum 25OHD lower than 20, 25, or 30 ng/mL, respectively. No differences in bone turnover markers were found when comparing patients with low 25OHD defined according to the different cutoffs. However, a cutoff of 25 ng/mL appeared to differentiate better than a cutoff of 30 ng/mL in those subjects with reduced femoral neck BMD. The PTH plateau occurred at 25OHD levels of 26–30 ng/mL. In conclusion, vitamin D deficiency is common in Sicilian postmenopausal women and it may be associated with low BMD and increased bone turnover markers. Further studies are needed to better define the right cutoff for normal vitamin D levels in postmenopausal women. |
| format | Article |
| id | doaj-art-e73c88dd51284801bc093e494748e2c9 |
| institution | OA Journals |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-e73c88dd51284801bc093e494748e2c92025-08-20T02:21:10ZengWileyInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/487463487463Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone TurnoverNicola Napoli0Rocky Strollo1Delia Sprini2Ernesto Maddaloni3Giovam Battista Rini4Enrico Carmina5Endocrinology and Diabetes, Universitá Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, ItalyEndocrinology and Diabetes, Universitá Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, ItalyDipartimento di Medicina Interna e Specialistica (DIMIS), Università di Palermo, Via del Vespro 129, 90127 Palermo, ItalyEndocrinology and Diabetes, Universitá Campus Bio-Medico di Roma, Via Alvaro del Portillo 21, 00128 Rome, ItalyDipartimento di Medicina Interna e Specialistica (DIMIS), Università di Palermo, Via del Vespro 129, 90127 Palermo, ItalyEndocrine Unit, Department of Medical and Biological Sciences, Universitá di Palermo, Via delle Croci 47, 90139 Palermo, ItalyIt is unclear which vitamin D status is optimal for bone health. In this study, we aimed to assess cutoffs of 25-hydroxyvitamin D (25OHD) derived by the literature (20, 25, or 30 ng/mL) in relation to bone turnover and bone mineral density (BMD). Serum 25OHD, PTH, osteocalcin, bone alkaline phosphatase, and C-telopeptide were measured in 274 consecutive postmenopausal women. BMD of the lumbar spine (L1–L4) and of femoral neck were also evaluated. 50 patients had normal BMD, while 124 had osteopenia and 100 had osteoporosis. 37.6%, 56.2%, and 70.8% subjects had serum 25OHD lower than 20, 25, or 30 ng/mL, respectively. No differences in bone turnover markers were found when comparing patients with low 25OHD defined according to the different cutoffs. However, a cutoff of 25 ng/mL appeared to differentiate better than a cutoff of 30 ng/mL in those subjects with reduced femoral neck BMD. The PTH plateau occurred at 25OHD levels of 26–30 ng/mL. In conclusion, vitamin D deficiency is common in Sicilian postmenopausal women and it may be associated with low BMD and increased bone turnover markers. Further studies are needed to better define the right cutoff for normal vitamin D levels in postmenopausal women.http://dx.doi.org/10.1155/2014/487463 |
| spellingShingle | Nicola Napoli Rocky Strollo Delia Sprini Ernesto Maddaloni Giovam Battista Rini Enrico Carmina Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover International Journal of Endocrinology |
| title | Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover |
| title_full | Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover |
| title_fullStr | Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover |
| title_full_unstemmed | Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover |
| title_short | Serum 25-OH Vitamin D in relation to Bone Mineral Density and Bone Turnover |
| title_sort | serum 25 oh vitamin d in relation to bone mineral density and bone turnover |
| url | http://dx.doi.org/10.1155/2014/487463 |
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