A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology

Introduction. Comorbid psychiatric disorders are frequent among patients affected by tinnitus. There are mutual clinical influences between tinnitus and psychiatric disorders, as well as neurobiological relations based on partially overlapping hodological and neuroplastic phenomena. The aim of the p...

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Main Authors: Massimo Salviati, Francesco Saverio Bersani, Giuseppe Valeriani, Amedeo Minichino, Roberta Panico, Graziella Francesca Romano, Filippo Mazzei, Valeria Testugini, Giancarlo Altissimi, Giancarlo Cianfrone
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2014/817852
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author Massimo Salviati
Francesco Saverio Bersani
Giuseppe Valeriani
Amedeo Minichino
Roberta Panico
Graziella Francesca Romano
Filippo Mazzei
Valeria Testugini
Giancarlo Altissimi
Giancarlo Cianfrone
author_facet Massimo Salviati
Francesco Saverio Bersani
Giuseppe Valeriani
Amedeo Minichino
Roberta Panico
Graziella Francesca Romano
Filippo Mazzei
Valeria Testugini
Giancarlo Altissimi
Giancarlo Cianfrone
author_sort Massimo Salviati
collection DOAJ
description Introduction. Comorbid psychiatric disorders are frequent among patients affected by tinnitus. There are mutual clinical influences between tinnitus and psychiatric disorders, as well as neurobiological relations based on partially overlapping hodological and neuroplastic phenomena. The aim of the present paper is to review the evidence of alterations in brain networks underlying tinnitus physiopathology and to discuss them in light of the current knowledge of the neurobiology of psychiatric disorders. Methods. Relevant literature was identified through a search on Medline and PubMed; search terms included tinnitus, brain, plasticity, cortex, network, and pathways. Results. Tinnitus phenomenon results from systemic-neurootological triggers followed by neuronal remapping within several auditory and nonauditory pathways. Plastic reorganization and white matter alterations within limbic system, arcuate fasciculus, insula, salience network, dorsolateral prefrontal cortex, auditory pathways, ffrontocortical, and thalamocortical networks are discussed. Discussion. Several overlapping brain network alterations do exist between tinnitus and psychiatric disorders. Tinnitus, initially related to a clinicoanatomical approach based on a cortical localizationism, could be better explained by an holistic or associationist approach considering psychic functions and tinnitus as emergent properties of partially overlapping large-scale neural networks.
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spelling doaj-art-e73c75048b4043239f563d935ab2d2852025-08-20T03:26:14ZengWileyNeural Plasticity2090-59041687-54432014-01-01201410.1155/2014/817852817852A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to HodologyMassimo Salviati0Francesco Saverio Bersani1Giuseppe Valeriani2Amedeo Minichino3Roberta Panico4Graziella Francesca Romano5Filippo Mazzei6Valeria Testugini7Giancarlo Altissimi8Giancarlo Cianfrone9Department of Sensory Organs, Sapienza University of Rome, Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, ItalyDepartment of Neurology and Psychiatry, Sapienza University of Rome, Rome, ItalyDepartment of Sensory Organs, Sapienza University of Rome, Rome, ItalyDepartment of Sensory Organs, Sapienza University of Rome, Rome, ItalyDepartment of Sensory Organs, Sapienza University of Rome, Rome, ItalyDepartment of Sensory Organs, Sapienza University of Rome, Rome, ItalyIntroduction. Comorbid psychiatric disorders are frequent among patients affected by tinnitus. There are mutual clinical influences between tinnitus and psychiatric disorders, as well as neurobiological relations based on partially overlapping hodological and neuroplastic phenomena. The aim of the present paper is to review the evidence of alterations in brain networks underlying tinnitus physiopathology and to discuss them in light of the current knowledge of the neurobiology of psychiatric disorders. Methods. Relevant literature was identified through a search on Medline and PubMed; search terms included tinnitus, brain, plasticity, cortex, network, and pathways. Results. Tinnitus phenomenon results from systemic-neurootological triggers followed by neuronal remapping within several auditory and nonauditory pathways. Plastic reorganization and white matter alterations within limbic system, arcuate fasciculus, insula, salience network, dorsolateral prefrontal cortex, auditory pathways, ffrontocortical, and thalamocortical networks are discussed. Discussion. Several overlapping brain network alterations do exist between tinnitus and psychiatric disorders. Tinnitus, initially related to a clinicoanatomical approach based on a cortical localizationism, could be better explained by an holistic or associationist approach considering psychic functions and tinnitus as emergent properties of partially overlapping large-scale neural networks.http://dx.doi.org/10.1155/2014/817852
spellingShingle Massimo Salviati
Francesco Saverio Bersani
Giuseppe Valeriani
Amedeo Minichino
Roberta Panico
Graziella Francesca Romano
Filippo Mazzei
Valeria Testugini
Giancarlo Altissimi
Giancarlo Cianfrone
A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology
Neural Plasticity
title A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology
title_full A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology
title_fullStr A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology
title_full_unstemmed A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology
title_short A Brain Centred View of Psychiatric Comorbidity in Tinnitus: From Otology to Hodology
title_sort brain centred view of psychiatric comorbidity in tinnitus from otology to hodology
url http://dx.doi.org/10.1155/2014/817852
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