The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice
The cytokine interleukin-1β (IL-1β) is known to stimulate proinflammatory immune responses and impair β-cell function and viability, all critical events in the pathogenesis of type 1 diabetes (T1D). Here we evaluate the effect of SER140, a small peptide IL-1β receptor antagonist, on diabetes progres...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/7484601 |
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| _version_ | 1849467482281082880 |
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| author | Helena Cucak Gitte Hansen Niels Vrang Torben Skarsfeldt Eva Steiness Jacob Jelsing |
| author_facet | Helena Cucak Gitte Hansen Niels Vrang Torben Skarsfeldt Eva Steiness Jacob Jelsing |
| author_sort | Helena Cucak |
| collection | DOAJ |
| description | The cytokine interleukin-1β (IL-1β) is known to stimulate proinflammatory immune responses and impair β-cell function and viability, all critical events in the pathogenesis of type 1 diabetes (T1D). Here we evaluate the effect of SER140, a small peptide IL-1β receptor antagonist, on diabetes progression and cellular pancreatic changes in female nonobese diabetic (NOD) mice. Eight weeks of treatment with SER140 reduced the incidence of diabetes by more than 50% compared with vehicle, decreased blood glucose, and increased plasma insulin. Additionally, SER140 changed the endocrine and immune cells dynamics in the NOD mouse pancreas. Together, the data suggest that SER140 treatment postpones the onset of diabetes in female NOD mice by interfering with IL-1β activated pathways. |
| format | Article |
| id | doaj-art-e73bf756afa04c55b061a33bcfdaeded |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-e73bf756afa04c55b061a33bcfdaeded2025-08-20T03:26:14ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/74846017484601The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic MiceHelena Cucak0Gitte Hansen1Niels Vrang2Torben Skarsfeldt3Eva Steiness4Jacob Jelsing5Gubra ApS, Agern Alle 1, 2970 Hørsholm, DenmarkGubra ApS, Agern Alle 1, 2970 Hørsholm, DenmarkGubra ApS, Agern Alle 1, 2970 Hørsholm, DenmarkSerodus ASA, Gaustadalléen 21, 0349 Oslo, NorwaySerodus ASA, Gaustadalléen 21, 0349 Oslo, NorwayGubra ApS, Agern Alle 1, 2970 Hørsholm, DenmarkThe cytokine interleukin-1β (IL-1β) is known to stimulate proinflammatory immune responses and impair β-cell function and viability, all critical events in the pathogenesis of type 1 diabetes (T1D). Here we evaluate the effect of SER140, a small peptide IL-1β receptor antagonist, on diabetes progression and cellular pancreatic changes in female nonobese diabetic (NOD) mice. Eight weeks of treatment with SER140 reduced the incidence of diabetes by more than 50% compared with vehicle, decreased blood glucose, and increased plasma insulin. Additionally, SER140 changed the endocrine and immune cells dynamics in the NOD mouse pancreas. Together, the data suggest that SER140 treatment postpones the onset of diabetes in female NOD mice by interfering with IL-1β activated pathways.http://dx.doi.org/10.1155/2016/7484601 |
| spellingShingle | Helena Cucak Gitte Hansen Niels Vrang Torben Skarsfeldt Eva Steiness Jacob Jelsing The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice Journal of Diabetes Research |
| title | The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice |
| title_full | The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice |
| title_fullStr | The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice |
| title_full_unstemmed | The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice |
| title_short | The IL-1β Receptor Antagonist SER140 Postpones the Onset of Diabetes in Female Nonobese Diabetic Mice |
| title_sort | il 1β receptor antagonist ser140 postpones the onset of diabetes in female nonobese diabetic mice |
| url | http://dx.doi.org/10.1155/2016/7484601 |
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