The association of cytokine levels and postnatal factors with retinopathy of prematurity
Purpose: Prematurity has been known to trigger several cellular pathways, leading to the clinical occurrence of retinopathy of prematurity (ROP). This study compared the levels of a panel of serum cytokines in premature infants with and without ROP. Methods: This is a prospective observational study...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.4103/IJO.IJO_515_24 |
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| author | Syatirah Abu Yazib May May Choo Nurliza Khaliddin Christine PY Ong Yao Mun Choo Azanna Ahmad Kamar Gopal G Lingam Tengku A Kamalden |
| author_facet | Syatirah Abu Yazib May May Choo Nurliza Khaliddin Christine PY Ong Yao Mun Choo Azanna Ahmad Kamar Gopal G Lingam Tengku A Kamalden |
| author_sort | Syatirah Abu Yazib |
| collection | DOAJ |
| description | Purpose:
Prematurity has been known to trigger several cellular pathways, leading to the clinical occurrence of retinopathy of prematurity (ROP). This study compared the levels of a panel of serum cytokines in premature infants with and without ROP.
Methods:
This is a prospective observational study. Premature infants at 36–38 weeks’ gestational age were recruited, their clinical data recorded, and serum samples collected and assayed for 18 cytokines. Based on follow-up examinations, patients were divided into two groups: No ROP and ROP. The ROP group was further divided into two subgroups: non-vision-threatening ROP (non-VTROP), and vision-threatening ROP (VTROP).
Results:
On univariate analysis, among the clinical parameters, gestation age, birth weight, duration of invasive ventilation, and duration of stay in neonatal intensive care unit (NICU) were found to be significant. The univariate analysis also showed an association between raised levels of VEGF-D and IL-8 in the VTROP group. Multiple logistic regression indicated that gestation age was a significant risk factor across all subgroups. Additionally, VEGF-D levels were found to be significantly associated with VTROP.
Conclusion:
Higher VEGF-D levels are associated with an increased risk of severe ROP that requires treatment and could potentially be used as a biomarker. |
| format | Article |
| id | doaj-art-e739575fc1874aa4aec50525b95ded08 |
| institution | DOAJ |
| issn | 0301-4738 1998-3689 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj-art-e739575fc1874aa4aec50525b95ded082025-08-20T02:45:28ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892025-01-0173Suppl 1S139S14310.4103/IJO.IJO_515_24The association of cytokine levels and postnatal factors with retinopathy of prematuritySyatirah Abu YazibMay May ChooNurliza KhaliddinChristine PY OngYao Mun ChooAzanna Ahmad KamarGopal G LingamTengku A KamaldenPurpose: Prematurity has been known to trigger several cellular pathways, leading to the clinical occurrence of retinopathy of prematurity (ROP). This study compared the levels of a panel of serum cytokines in premature infants with and without ROP. Methods: This is a prospective observational study. Premature infants at 36–38 weeks’ gestational age were recruited, their clinical data recorded, and serum samples collected and assayed for 18 cytokines. Based on follow-up examinations, patients were divided into two groups: No ROP and ROP. The ROP group was further divided into two subgroups: non-vision-threatening ROP (non-VTROP), and vision-threatening ROP (VTROP). Results: On univariate analysis, among the clinical parameters, gestation age, birth weight, duration of invasive ventilation, and duration of stay in neonatal intensive care unit (NICU) were found to be significant. The univariate analysis also showed an association between raised levels of VEGF-D and IL-8 in the VTROP group. Multiple logistic regression indicated that gestation age was a significant risk factor across all subgroups. Additionally, VEGF-D levels were found to be significantly associated with VTROP. Conclusion: Higher VEGF-D levels are associated with an increased risk of severe ROP that requires treatment and could potentially be used as a biomarker.https://journals.lww.com/10.4103/IJO.IJO_515_24cytokinesretinopathy of prematurityrop |
| spellingShingle | Syatirah Abu Yazib May May Choo Nurliza Khaliddin Christine PY Ong Yao Mun Choo Azanna Ahmad Kamar Gopal G Lingam Tengku A Kamalden The association of cytokine levels and postnatal factors with retinopathy of prematurity Indian Journal of Ophthalmology cytokines retinopathy of prematurity rop |
| title | The association of cytokine levels and postnatal factors with retinopathy of prematurity |
| title_full | The association of cytokine levels and postnatal factors with retinopathy of prematurity |
| title_fullStr | The association of cytokine levels and postnatal factors with retinopathy of prematurity |
| title_full_unstemmed | The association of cytokine levels and postnatal factors with retinopathy of prematurity |
| title_short | The association of cytokine levels and postnatal factors with retinopathy of prematurity |
| title_sort | association of cytokine levels and postnatal factors with retinopathy of prematurity |
| topic | cytokines retinopathy of prematurity rop |
| url | https://journals.lww.com/10.4103/IJO.IJO_515_24 |
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