gamma-H2AX: Can it be established as a classical cancer prognostic factor?
Double-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to double-strand breaks, and the gamma-H2AX is formatted as a result of genomic ins...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695931 |
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| _version_ | 1849697660945039360 |
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| author | Viktoria-Varvara Palla Georgios Karaolanis Ioannis Katafigiotis Ioannis Anastasiou Paul Patapis Dimitrios Dimitroulis Despoina Perrea |
| author_facet | Viktoria-Varvara Palla Georgios Karaolanis Ioannis Katafigiotis Ioannis Anastasiou Paul Patapis Dimitrios Dimitroulis Despoina Perrea |
| author_sort | Viktoria-Varvara Palla |
| collection | DOAJ |
| description | Double-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to double-strand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor. |
| format | Article |
| id | doaj-art-e737a7392cd6430fab72c38c993f8e8a |
| institution | DOAJ |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-e737a7392cd6430fab72c38c993f8e8a2025-08-20T03:19:08ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317695931gamma-H2AX: Can it be established as a classical cancer prognostic factor?Viktoria-Varvara Palla0Georgios Karaolanis1Ioannis Katafigiotis2Ioannis Anastasiou3Paul Patapis4Dimitrios Dimitroulis5Despoina Perrea6Department of Obstetrics and Gynecology, Diakonie-Klinikum Schwäbisch Hall, Schwäbisch Hall, Germany1st Department of Surgery, Vascular Unit, Laiko General Hospital, Medical School of Athens, Athens, Greece1st University Urology Clinic, Laiko Hospital, University of Athens, Athens, Greece1st University Urology Clinic, Laiko Hospital, University of Athens, Athens, Greece3rd Department of Surgery, Attikon General Hospital, University of Athens, Athens, Greece2nd Department of Surgery, Laiko Hospital, University of Athens, Athens, Greece2nd Department of Surgery, Laiko Hospital, University of Athens, Athens, GreeceDouble-strand breaks are among the first procedures taking place in cancer formation and progression as a result of endogenic and exogenic factors. The histone variant H2AX undergoes phosphorylation at serine 139 due to double-strand breaks, and the gamma-H2AX is formatted as a result of genomic instability. The detection of gamma-H2AX can potentially serve as a biomarker for transformation of normal tissue to premalignant and consequently to malignant tissues. gamma-H2AX has already been investigated in a variety of cancer types, including breast, lung, colon, cervix, and ovary cancers. The prognostic value of gamma-H2AX is indicated in certain cancer types, such as breast or endometrial cancer, but further investigation is needed to establish gamma-H2AX as a prognostic marker. This review outlines the role of gamma-H2AX in cell cycle, and its formation as a result of DNA damage. We investigate the role of gamma-H2AX formation in several cancer types and its correlation with other prognostic factors, and we try to find out whether it fulfills the requirements for its establishment as a classical cancer prognostic factor.https://doi.org/10.1177/1010428317695931 |
| spellingShingle | Viktoria-Varvara Palla Georgios Karaolanis Ioannis Katafigiotis Ioannis Anastasiou Paul Patapis Dimitrios Dimitroulis Despoina Perrea gamma-H2AX: Can it be established as a classical cancer prognostic factor? Tumor Biology |
| title | gamma-H2AX: Can it be established as a classical cancer prognostic factor? |
| title_full | gamma-H2AX: Can it be established as a classical cancer prognostic factor? |
| title_fullStr | gamma-H2AX: Can it be established as a classical cancer prognostic factor? |
| title_full_unstemmed | gamma-H2AX: Can it be established as a classical cancer prognostic factor? |
| title_short | gamma-H2AX: Can it be established as a classical cancer prognostic factor? |
| title_sort | gamma h2ax can it be established as a classical cancer prognostic factor |
| url | https://doi.org/10.1177/1010428317695931 |
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