Somatic problems of HIV-Medicine: AIDS-related lymphomas
We followed 66 lymphoma -AIDS patients (pts): aggressive lymphomas were diagnosed in 48 pts (male — 35, female — 13, median age 32.5±1.2) and Hodgkin's lymphoma was established in 18 pts (male — 14, female — 4, median age 34.1±2.3). Median duration time from HIV exposure to the onset of lymphom...
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2022-11-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/632 |
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| author | A. V. Pivnik Y. G. Parhomenko Y. A. Krivolapov O. A. Tishkevich V. G. Korovushkin A. M. Kovrigina M. B. Grusdev L. D. Grinshpun I. A. Berdisheva N. V. Seregin A. O. Tuaeva E. B. Likunov D. V. Boyko |
| author_facet | A. V. Pivnik Y. G. Parhomenko Y. A. Krivolapov O. A. Tishkevich V. G. Korovushkin A. M. Kovrigina M. B. Grusdev L. D. Grinshpun I. A. Berdisheva N. V. Seregin A. O. Tuaeva E. B. Likunov D. V. Boyko |
| author_sort | A. V. Pivnik |
| collection | DOAJ |
| description | We followed 66 lymphoma -AIDS patients (pts): aggressive lymphomas were diagnosed in 48 pts (male — 35, female — 13, median age 32.5±1.2) and Hodgkin's lymphoma was established in 18 pts (male — 14, female — 4, median age 34.1±2.3). Median duration time from HIV exposure to the onset of lymphomas was 5 years (2—16 years). A part of pts was receiving HAART. 85 % of pts were drug users and association with HCV was shown in 60 % of them, with HCV and HBV- in 25 %. Sexual transmission was mentioned in 15 % of pts. «Immune status»: CD4 counts were from 50 to 500 (median 225) cells in mcL. Viral load was from 400 to 75000 (median 38000) copies in mcL. Histological diagnosis: diffuse large cell lymphomas — 60%, Burkitt lymphoma — 16%, follicular lymphoma — 12%, MALT-lymphomas-6%, T- cell lymphoma — 4%, primary CNS lymphoma — 2%. CHOP and CHOP-like courses had received 26 pts. Results: 3-year overall survival — 52%, 3-year disease free survival — 32%. Block therapy A-B-C of BFM — NHL— 90 and LB-M-04 with and without Mabthera had received 12 pts. Results: 3-year overall survival — 48%, 3-year disease free survival — 38%. After treatment CD4 count was 60 — 700 (median 316) cells in mcL, viral load 400 to 25000 (median 3000) copies in mcL. 75% of Hodgkin's lymphoma patients had III—IV stages of disease. Initial immune status: CD4 counts from 50 to 730 (median 363) cells in mcL, viral load — from 14000 to 150 000 (median 100 000) copies in mcL. Histological variants: mixed cellularity — 14 pts, lymphoid depletion — 3 pts, nodular sclerosis — 1 pt. Chemotherapy had received 11 pts: ABVD with or without radiotherapy — 8 pts, BEACOPP-escalated with or without radiotherapy — 3 pts. Complete 3-year remissions were achieved in 2 pts. Other pts are on therapy. After treatment CD4 counts were 184 — 900 (median 400) cells in mcL, viral load — 435000 (median 100 000) copies in mcL. Modern treatment approaches in lymphoma -AIDS pts can lead to complete remission, as well as in general non-HIV positive population. |
| format | Article |
| id | doaj-art-e7356726dc7d4534a45aef59608aa874 |
| institution | DOAJ |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2022-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-e7356726dc7d4534a45aef59608aa8742025-08-20T03:01:03ZrusABV-pressОнкогематология1818-83462413-40232022-11-0103273710.17650/1818-8346-2007-0-3-27-37510Somatic problems of HIV-Medicine: AIDS-related lymphomasA. V. Pivnik0Y. G. Parhomenko1Y. A. Krivolapov2O. A. Tishkevich3V. G. Korovushkin4A. M. Kovrigina5M. B. Grusdev6L. D. Grinshpun7I. A. Berdisheva8N. V. Seregin9A. O. Tuaeva10E. B. Likunov11D. V. Boyko12N.I. Pirogov's National Medico-Surgical Center, Clinic and Chair of hematologyInfectious City Hospital № 2Leningrad Regional Pathology BureauInfectious City Hospital № 2Infectious City Hospital № 2N.N. Blokhin's Cancer Research CenterInfectious City Hospital № 2Clinical City Hospital № 60Clinical City Hospital № 60Clinical City Hospital № 60Clinical City Hospital № 60Federal Research Center of pediatric hematology, oncology and immunologyMedical AcademyWe followed 66 lymphoma -AIDS patients (pts): aggressive lymphomas were diagnosed in 48 pts (male — 35, female — 13, median age 32.5±1.2) and Hodgkin's lymphoma was established in 18 pts (male — 14, female — 4, median age 34.1±2.3). Median duration time from HIV exposure to the onset of lymphomas was 5 years (2—16 years). A part of pts was receiving HAART. 85 % of pts were drug users and association with HCV was shown in 60 % of them, with HCV and HBV- in 25 %. Sexual transmission was mentioned in 15 % of pts. «Immune status»: CD4 counts were from 50 to 500 (median 225) cells in mcL. Viral load was from 400 to 75000 (median 38000) copies in mcL. Histological diagnosis: diffuse large cell lymphomas — 60%, Burkitt lymphoma — 16%, follicular lymphoma — 12%, MALT-lymphomas-6%, T- cell lymphoma — 4%, primary CNS lymphoma — 2%. CHOP and CHOP-like courses had received 26 pts. Results: 3-year overall survival — 52%, 3-year disease free survival — 32%. Block therapy A-B-C of BFM — NHL— 90 and LB-M-04 with and without Mabthera had received 12 pts. Results: 3-year overall survival — 48%, 3-year disease free survival — 38%. After treatment CD4 count was 60 — 700 (median 316) cells in mcL, viral load 400 to 25000 (median 3000) copies in mcL. 75% of Hodgkin's lymphoma patients had III—IV stages of disease. Initial immune status: CD4 counts from 50 to 730 (median 363) cells in mcL, viral load — from 14000 to 150 000 (median 100 000) copies in mcL. Histological variants: mixed cellularity — 14 pts, lymphoid depletion — 3 pts, nodular sclerosis — 1 pt. Chemotherapy had received 11 pts: ABVD with or without radiotherapy — 8 pts, BEACOPP-escalated with or without radiotherapy — 3 pts. Complete 3-year remissions were achieved in 2 pts. Other pts are on therapy. After treatment CD4 counts were 184 — 900 (median 400) cells in mcL, viral load — 435000 (median 100 000) copies in mcL. Modern treatment approaches in lymphoma -AIDS pts can lead to complete remission, as well as in general non-HIV positive population.https://oncohematology.abvpress.ru/ongm/article/view/632aids-lymphomas in russiadiagnosis and treatment |
| spellingShingle | A. V. Pivnik Y. G. Parhomenko Y. A. Krivolapov O. A. Tishkevich V. G. Korovushkin A. M. Kovrigina M. B. Grusdev L. D. Grinshpun I. A. Berdisheva N. V. Seregin A. O. Tuaeva E. B. Likunov D. V. Boyko Somatic problems of HIV-Medicine: AIDS-related lymphomas Онкогематология aids-lymphomas in russia diagnosis and treatment |
| title | Somatic problems of HIV-Medicine: AIDS-related lymphomas |
| title_full | Somatic problems of HIV-Medicine: AIDS-related lymphomas |
| title_fullStr | Somatic problems of HIV-Medicine: AIDS-related lymphomas |
| title_full_unstemmed | Somatic problems of HIV-Medicine: AIDS-related lymphomas |
| title_short | Somatic problems of HIV-Medicine: AIDS-related lymphomas |
| title_sort | somatic problems of hiv medicine aids related lymphomas |
| topic | aids-lymphomas in russia diagnosis and treatment |
| url | https://oncohematology.abvpress.ru/ongm/article/view/632 |
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