Prevalence of Types TEM, SHV and CTX-M /3LES Among Pathogens of Chronic Pyelonephritis
There Is lately observed an increase in the resistance of the main pathogens of urologie infection to β-lactam antibiotics due to production of plasmid-induced в-lactamases. The aim of the study was to reveal types TEM, SHV and CTX-M plasmid β-lactamases among uropathogens. Out of 115 isolates, 30 (...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/576 |
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| author | A. V. Bilchenko O. I. Chub |
| author_facet | A. V. Bilchenko O. I. Chub |
| author_sort | A. V. Bilchenko |
| collection | DOAJ |
| description | There Is lately observed an increase in the resistance of the main pathogens of urologie infection to β-lactam antibiotics due to production of plasmid-induced в-lactamases. The aim of the study was to reveal types TEM, SHV and CTX-M plasmid β-lactamases among uropathogens. Out of 115 isolates, 30 (26.1%) strains produced β-lactamases. Genes blaTEM and blaCTX-Mwere the most frequent. Most of the isolates were resistant to ampicillin (73.3%), ciprofloxacin (46.7%), levofloxacin (43.3%), gentamicin (40%). The βLES-producing strains were susceptible to meropenem (96.7%), nitroxolin (83.3%), phosphomycin (70%), amikacin (70%). The presence of the resistance genes in the uropathogens was evident of a high rate of their distribution among them by the plasmids. Detection of the plasmid-induced β-lactamases is important for the optimal choice of the antibiotic for empirical therapy. |
| format | Article |
| id | doaj-art-e731434d8ff9430fa55f6feeeef53133 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-e731434d8ff9430fa55f6feeeef531332025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-015911-122426575Prevalence of Types TEM, SHV and CTX-M /3LES Among Pathogens of Chronic PyelonephritisA. V. Bilchenko0O. I. Chub1Kharkov Medical Academy of Postgraduate EducationKharkov Medical Academy of Postgraduate EducationThere Is lately observed an increase in the resistance of the main pathogens of urologie infection to β-lactam antibiotics due to production of plasmid-induced в-lactamases. The aim of the study was to reveal types TEM, SHV and CTX-M plasmid β-lactamases among uropathogens. Out of 115 isolates, 30 (26.1%) strains produced β-lactamases. Genes blaTEM and blaCTX-Mwere the most frequent. Most of the isolates were resistant to ampicillin (73.3%), ciprofloxacin (46.7%), levofloxacin (43.3%), gentamicin (40%). The βLES-producing strains were susceptible to meropenem (96.7%), nitroxolin (83.3%), phosphomycin (70%), amikacin (70%). The presence of the resistance genes in the uropathogens was evident of a high rate of their distribution among them by the plasmids. Detection of the plasmid-induced β-lactamases is important for the optimal choice of the antibiotic for empirical therapy.https://www.antibiotics-chemotherapy.ru/jour/article/view/576urologic infectionpathogensβles |
| spellingShingle | A. V. Bilchenko O. I. Chub Prevalence of Types TEM, SHV and CTX-M /3LES Among Pathogens of Chronic Pyelonephritis Антибиотики и Химиотерапия urologic infection pathogens βles |
| title | Prevalence of Types TEM, SHV and CTX-M /3LES Among Pathogens of Chronic Pyelonephritis |
| title_full | Prevalence of Types TEM, SHV and CTX-M /3LES Among Pathogens of Chronic Pyelonephritis |
| title_fullStr | Prevalence of Types TEM, SHV and CTX-M /3LES Among Pathogens of Chronic Pyelonephritis |
| title_full_unstemmed | Prevalence of Types TEM, SHV and CTX-M /3LES Among Pathogens of Chronic Pyelonephritis |
| title_short | Prevalence of Types TEM, SHV and CTX-M /3LES Among Pathogens of Chronic Pyelonephritis |
| title_sort | prevalence of types tem shv and ctx m 3les among pathogens of chronic pyelonephritis |
| topic | urologic infection pathogens βles |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/576 |
| work_keys_str_mv | AT avbilchenko prevalenceoftypestemshvandctxm3lesamongpathogensofchronicpyelonephritis AT oichub prevalenceoftypestemshvandctxm3lesamongpathogensofchronicpyelonephritis |