The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice
Abstract The biologically active peptides derived from broad bean protein, including broad bean albumin 1b (BA1b), have anti-oxidation and anti-glycation effects. However, the potential for BA1b to improve glucose metabolism and the underlying mechanisms remain unexplored. We examined the effects of...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-06-01
|
| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00486-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850109632593264640 |
|---|---|
| author | Feifei Han Lu Jin Lulu Zhou Qi Liu MengLu Ding Weilin Liu Jianzhong Han |
| author_facet | Feifei Han Lu Jin Lulu Zhou Qi Liu MengLu Ding Weilin Liu Jianzhong Han |
| author_sort | Feifei Han |
| collection | DOAJ |
| description | Abstract The biologically active peptides derived from broad bean protein, including broad bean albumin 1b (BA1b), have anti-oxidation and anti-glycation effects. However, the potential for BA1b to improve glucose metabolism and the underlying mechanisms remain unexplored. We examined the effects of BA1b on glucose metabolism in diabetic mice and further studied the effects of BA1b on intestinal cells based on small intestinal organoids (SIOs). The results showed that BA1b significantly reduced blood glucose and serum insulin levels, promoted secretion of glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) in diabetic mice. Similarly, BA1b significantly increased the secretion of GIP and GLP-1 levels in SIOs. Mechanistic studies found that BA1b promoted the secretion of incretin (GIP and GLP-1) by up-regulation of VDAC1 gene expression levels. These findings emphasized the important role of BA1b in improving glucose metabolism and provided a new insight into strategies to explore the effects of functional foods. |
| format | Article |
| id | doaj-art-e72f6928069d4772bec33f4ff5bfca60 |
| institution | OA Journals |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-e72f6928069d4772bec33f4ff5bfca602025-08-20T02:38:01ZengNature Portfolionpj Science of Food2396-83702025-06-019111110.1038/s41538-025-00486-9The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic miceFeifei Han0Lu Jin1Lulu Zhou2Qi Liu3MengLu Ding4Weilin Liu5Jianzhong Han6School of Food Science and Biotechnology, Zhejiang Gongshang UniversitySchool of Food Science and Biotechnology, Zhejiang Gongshang UniversitySchool of Food Science and Biotechnology, Zhejiang Gongshang UniversitySchool of Food Science and Biotechnology, Zhejiang Gongshang UniversitySchool of Food Science and Biotechnology, Zhejiang Gongshang UniversitySchool of Food Science and Biotechnology, Zhejiang Gongshang UniversitySchool of Food Science and Biotechnology, Zhejiang Gongshang UniversityAbstract The biologically active peptides derived from broad bean protein, including broad bean albumin 1b (BA1b), have anti-oxidation and anti-glycation effects. However, the potential for BA1b to improve glucose metabolism and the underlying mechanisms remain unexplored. We examined the effects of BA1b on glucose metabolism in diabetic mice and further studied the effects of BA1b on intestinal cells based on small intestinal organoids (SIOs). The results showed that BA1b significantly reduced blood glucose and serum insulin levels, promoted secretion of glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) in diabetic mice. Similarly, BA1b significantly increased the secretion of GIP and GLP-1 levels in SIOs. Mechanistic studies found that BA1b promoted the secretion of incretin (GIP and GLP-1) by up-regulation of VDAC1 gene expression levels. These findings emphasized the important role of BA1b in improving glucose metabolism and provided a new insight into strategies to explore the effects of functional foods.https://doi.org/10.1038/s41538-025-00486-9 |
| spellingShingle | Feifei Han Lu Jin Lulu Zhou Qi Liu MengLu Ding Weilin Liu Jianzhong Han The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice npj Science of Food |
| title | The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice |
| title_full | The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice |
| title_fullStr | The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice |
| title_full_unstemmed | The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice |
| title_short | The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice |
| title_sort | role of broad bean albumin 1b on gip and glp 1 mediated alterations to glucose metabolism in diabetic mice |
| url | https://doi.org/10.1038/s41538-025-00486-9 |
| work_keys_str_mv | AT feifeihan theroleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT lujin theroleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT luluzhou theroleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT qiliu theroleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT mengluding theroleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT weilinliu theroleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT jianzhonghan theroleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT feifeihan roleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT lujin roleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT luluzhou roleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT qiliu roleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT mengluding roleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT weilinliu roleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice AT jianzhonghan roleofbroadbeanalbumin1bongipandglp1mediatedalterationstoglucosemetabolismindiabeticmice |