The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair
The Wilms’ tumor suppressor WT1 is essential for the development of the heart, among other organs such as the kidneys and gonads. The Wt1 gene encodes a zinc finger transcription factor that regulates proliferation, cellular differentiation processes, and apoptosis. WT1 is also involved in cardiac h...
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MDPI AG
2024-12-01
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| author | Sandra Díaz del Moral Nicole Wagner Kay-Dietrich Wagner |
| author_facet | Sandra Díaz del Moral Nicole Wagner Kay-Dietrich Wagner |
| author_sort | Sandra Díaz del Moral |
| collection | DOAJ |
| description | The Wilms’ tumor suppressor WT1 is essential for the development of the heart, among other organs such as the kidneys and gonads. The Wt1 gene encodes a zinc finger transcription factor that regulates proliferation, cellular differentiation processes, and apoptosis. WT1 is also involved in cardiac homeostasis and repair. In adulthood, WT1-expression levels are lower compared to those observed through development, and WT1 expression is restricted to a few cell types. However, its systemic deletion in adult mice is lethal, demonstrating that its presence is also key for organ maintenance. In response to injury, the epicardium re-activates the expression of WT1, but little is known about the roles it plays in cardiomyocytes, which are the main cell type affected after myocardial infarction. The fact that cardiomyocytes exhibit a low proliferation rate in the adult heart in mammals highlights the need to explore new approaches for cardiac regeneration. The aim of this review is to emphasize the functions carried out by WT1 in cardiomyocytes in cardiac homeostasis and heart regeneration. |
| format | Article |
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| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj-art-e72e937bec234edea8517ff8849bff962025-08-20T02:00:43ZengMDPI AGCells2073-44092024-12-011324207810.3390/cells13242078The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and RepairSandra Díaz del Moral0Nicole Wagner1Kay-Dietrich Wagner2Université Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, FranceUniversité Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, FranceUniversité Côte d’Azur, CNRS, INSERM, iBV, 06107 Nice, FranceThe Wilms’ tumor suppressor WT1 is essential for the development of the heart, among other organs such as the kidneys and gonads. The Wt1 gene encodes a zinc finger transcription factor that regulates proliferation, cellular differentiation processes, and apoptosis. WT1 is also involved in cardiac homeostasis and repair. In adulthood, WT1-expression levels are lower compared to those observed through development, and WT1 expression is restricted to a few cell types. However, its systemic deletion in adult mice is lethal, demonstrating that its presence is also key for organ maintenance. In response to injury, the epicardium re-activates the expression of WT1, but little is known about the roles it plays in cardiomyocytes, which are the main cell type affected after myocardial infarction. The fact that cardiomyocytes exhibit a low proliferation rate in the adult heart in mammals highlights the need to explore new approaches for cardiac regeneration. The aim of this review is to emphasize the functions carried out by WT1 in cardiomyocytes in cardiac homeostasis and heart regeneration.https://www.mdpi.com/2073-4409/13/24/2078Wilms’ tumor suppressor 1 (WT1)cardiomyocyteepicardial cellsepicardiumhearthomeostasis |
| spellingShingle | Sandra Díaz del Moral Nicole Wagner Kay-Dietrich Wagner The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair Cells Wilms’ tumor suppressor 1 (WT1) cardiomyocyte epicardial cells epicardium heart homeostasis |
| title | The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair |
| title_full | The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair |
| title_fullStr | The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair |
| title_full_unstemmed | The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair |
| title_short | The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair |
| title_sort | wilms tumor suppressor wt1 in cardiomyocytes implications for cardiac homeostasis and repair |
| topic | Wilms’ tumor suppressor 1 (WT1) cardiomyocyte epicardial cells epicardium heart homeostasis |
| url | https://www.mdpi.com/2073-4409/13/24/2078 |
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