Deep generalizable prediction of RNA secondary structure via base pair motif energy

Abstract Deep learning methods have demonstrated great performance for RNA secondary structure prediction. However, generalizability is a common unsolved issue on unseen out-of-distribution RNA families, which hinders further improvement of the accuracy and robustness of deep learning methods. Here...

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Bibliographic Details
Main Authors: Heqin Zhu, Fenghe Tang, Quan Quan, Ke Chen, Peng Xiong, S. Kevin Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60048-1
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