Acupoint Injection of Autologous Stromal Vascular Fraction and Allogeneic Adipose-Derived Stem Cells to Treat Hip Dysplasia in Dogs
Stem cells isolated from adipose tissue show great therapeutic potential in veterinary medicine, but some points such as the use of fresh or cultured cells and route of administration need better knowledge. This study aimed to evaluate the effect of autologous stromal vascular fraction (SVF, n=4) or...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2014/391274 |
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| author | Camila Marx Maiele Dornelles Silveira Isabel Selbach Ariel Silveira da Silva Luisa Maria Gomes de Macedo Braga Melissa Camassola Nance Beyer Nardi |
| author_facet | Camila Marx Maiele Dornelles Silveira Isabel Selbach Ariel Silveira da Silva Luisa Maria Gomes de Macedo Braga Melissa Camassola Nance Beyer Nardi |
| author_sort | Camila Marx |
| collection | DOAJ |
| description | Stem cells isolated from adipose tissue show great therapeutic potential in veterinary medicine, but some points such as the use of fresh or cultured cells and route of administration need better knowledge. This study aimed to evaluate the effect of autologous stromal vascular fraction (SVF, n=4) or allogeneic cultured adipose-derived stem cells (ASCs, n=5) injected into acupuncture points in dogs with hip dysplasia and weak response to drug therapy. Canine ASCs have proliferation and differentiation potential similar to ASCs from other species. After the first week of treatment, clinical evaluation showed marked improvement compared with baseline results in all patients treated with autologous SVF and three of the dogs treated with allogeneic ASCs. On days 15 and 30, all dogs showed improvement in range of motion, lameness at trot, and pain on manipulation of the joints, except for one ASC-treated patient. Positive results were more clearly seen in the SVF-treated group. These results show that autologous SVF or allogeneic ASCs can be safely used in acupoint injection for treating hip dysplasia in dogs and represent an important therapeutic alternative for this type of pathology. Further studies are necessary to assess a possible advantage of SVF cells in treating joint diseases. |
| format | Article |
| id | doaj-art-e72d1d4c8b4f41bc9ea097868f2ede2f |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e72d1d4c8b4f41bc9ea097868f2ede2f2025-08-20T03:26:11ZengWileyStem Cells International1687-966X1687-96782014-01-01201410.1155/2014/391274391274Acupoint Injection of Autologous Stromal Vascular Fraction and Allogeneic Adipose-Derived Stem Cells to Treat Hip Dysplasia in DogsCamila Marx0Maiele Dornelles Silveira1Isabel Selbach2Ariel Silveira da Silva3Luisa Maria Gomes de Macedo Braga4Melissa Camassola5Nance Beyer Nardi6Laboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, BrazilLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, BrazilClinivetis Clinica Veterinaria, 93310-500 Novo Hamburgo, RS, BrazilLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, BrazilCenter for Experimental Biological Models, Pontificia Universidade Catolica do Rio Grande do Sul, 90619-900 Porto Alegre, RS, BrazilLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, BrazilLaboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil, 92425-900 Canoas, RS, BrazilStem cells isolated from adipose tissue show great therapeutic potential in veterinary medicine, but some points such as the use of fresh or cultured cells and route of administration need better knowledge. This study aimed to evaluate the effect of autologous stromal vascular fraction (SVF, n=4) or allogeneic cultured adipose-derived stem cells (ASCs, n=5) injected into acupuncture points in dogs with hip dysplasia and weak response to drug therapy. Canine ASCs have proliferation and differentiation potential similar to ASCs from other species. After the first week of treatment, clinical evaluation showed marked improvement compared with baseline results in all patients treated with autologous SVF and three of the dogs treated with allogeneic ASCs. On days 15 and 30, all dogs showed improvement in range of motion, lameness at trot, and pain on manipulation of the joints, except for one ASC-treated patient. Positive results were more clearly seen in the SVF-treated group. These results show that autologous SVF or allogeneic ASCs can be safely used in acupoint injection for treating hip dysplasia in dogs and represent an important therapeutic alternative for this type of pathology. Further studies are necessary to assess a possible advantage of SVF cells in treating joint diseases.http://dx.doi.org/10.1155/2014/391274 |
| spellingShingle | Camila Marx Maiele Dornelles Silveira Isabel Selbach Ariel Silveira da Silva Luisa Maria Gomes de Macedo Braga Melissa Camassola Nance Beyer Nardi Acupoint Injection of Autologous Stromal Vascular Fraction and Allogeneic Adipose-Derived Stem Cells to Treat Hip Dysplasia in Dogs Stem Cells International |
| title | Acupoint Injection of Autologous Stromal Vascular Fraction and Allogeneic Adipose-Derived Stem Cells to Treat Hip Dysplasia in Dogs |
| title_full | Acupoint Injection of Autologous Stromal Vascular Fraction and Allogeneic Adipose-Derived Stem Cells to Treat Hip Dysplasia in Dogs |
| title_fullStr | Acupoint Injection of Autologous Stromal Vascular Fraction and Allogeneic Adipose-Derived Stem Cells to Treat Hip Dysplasia in Dogs |
| title_full_unstemmed | Acupoint Injection of Autologous Stromal Vascular Fraction and Allogeneic Adipose-Derived Stem Cells to Treat Hip Dysplasia in Dogs |
| title_short | Acupoint Injection of Autologous Stromal Vascular Fraction and Allogeneic Adipose-Derived Stem Cells to Treat Hip Dysplasia in Dogs |
| title_sort | acupoint injection of autologous stromal vascular fraction and allogeneic adipose derived stem cells to treat hip dysplasia in dogs |
| url | http://dx.doi.org/10.1155/2014/391274 |
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