Prolactin May Not Play a Role in Primary Antiphospholipid (Hughes') Syndrome
The relationship between prolactin (PRL) and the immune system has been demonstrated in the last two decades and has opened new windows in the field of immunoendocrinology. However, there are scarce reports about PRL in primary antiphospholipid syndrome (pAPS). The objective of this study was to eva...
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| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/248243 |
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| author | Manoel Tavares Neves Junior Carlos Ewerton Maia Rodrigues Jozelio Freire de Carvalho |
| author_facet | Manoel Tavares Neves Junior Carlos Ewerton Maia Rodrigues Jozelio Freire de Carvalho |
| author_sort | Manoel Tavares Neves Junior |
| collection | DOAJ |
| description | The relationship between prolactin (PRL) and the immune system has been demonstrated in the last two decades and has opened new windows in the field of immunoendocrinology. However, there are scarce reports about PRL in primary antiphospholipid syndrome (pAPS). The objective of this study was to evaluate PRL levels in patients with pAPS compared to healthy controls and to investigate their possible clinical associations. Fifty-five pAPS patients according to Sapporo criteria were age- and sex-matched with 41 healthy subjects. Individuals with secondary causes of hyperprolactinemia (HPRL) were excluded; demographic, biometric, and clinical data, PRL levels, antiphospholipid antibodies, inflammatory markers, and other routine laboratory findings were analyzed. PRL levels were similar between pAPS and healthy controls (8.94±7.02 versus 8.71±6.73 ng/mL, P=.876). Nine percent of the pAPS patients and 12.1% of the control subjects presented HPRL (P=.740). Comparison between the pAPS patients with hyper- and normoprolactinemia revealed no significant differences related to anthropometrics, clinical manifestations, medications, smoking, and antiphospholipid antibodies (P>.05). This study showed that HPRL does not seem to play a role in clinical manifestations of the pAPS, differently from other autoimmune rheumatic diseases. |
| format | Article |
| id | doaj-art-e72cd8684fdb4c70bf52ae784591a368 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-e72cd8684fdb4c70bf52ae784591a3682025-08-20T03:26:11ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/248243248243Prolactin May Not Play a Role in Primary Antiphospholipid (Hughes') SyndromeManoel Tavares Neves Junior0Carlos Ewerton Maia Rodrigues1Jozelio Freire de Carvalho2Disciplina de Reumatologia, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo, No. 455, 3 Andar, Sala 3190, 01246-903 Sao Paulo, SP, BrazilDisciplina de Reumatologia, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo, No. 455, 3 Andar, Sala 3190, 01246-903 Sao Paulo, SP, BrazilDisciplina de Reumatologia, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Arnaldo, No. 455, 3 Andar, Sala 3190, 01246-903 Sao Paulo, SP, BrazilThe relationship between prolactin (PRL) and the immune system has been demonstrated in the last two decades and has opened new windows in the field of immunoendocrinology. However, there are scarce reports about PRL in primary antiphospholipid syndrome (pAPS). The objective of this study was to evaluate PRL levels in patients with pAPS compared to healthy controls and to investigate their possible clinical associations. Fifty-five pAPS patients according to Sapporo criteria were age- and sex-matched with 41 healthy subjects. Individuals with secondary causes of hyperprolactinemia (HPRL) were excluded; demographic, biometric, and clinical data, PRL levels, antiphospholipid antibodies, inflammatory markers, and other routine laboratory findings were analyzed. PRL levels were similar between pAPS and healthy controls (8.94±7.02 versus 8.71±6.73 ng/mL, P=.876). Nine percent of the pAPS patients and 12.1% of the control subjects presented HPRL (P=.740). Comparison between the pAPS patients with hyper- and normoprolactinemia revealed no significant differences related to anthropometrics, clinical manifestations, medications, smoking, and antiphospholipid antibodies (P>.05). This study showed that HPRL does not seem to play a role in clinical manifestations of the pAPS, differently from other autoimmune rheumatic diseases.http://dx.doi.org/10.1155/2011/248243 |
| spellingShingle | Manoel Tavares Neves Junior Carlos Ewerton Maia Rodrigues Jozelio Freire de Carvalho Prolactin May Not Play a Role in Primary Antiphospholipid (Hughes') Syndrome Clinical and Developmental Immunology |
| title | Prolactin May Not Play a Role in Primary Antiphospholipid (Hughes') Syndrome |
| title_full | Prolactin May Not Play a Role in Primary Antiphospholipid (Hughes') Syndrome |
| title_fullStr | Prolactin May Not Play a Role in Primary Antiphospholipid (Hughes') Syndrome |
| title_full_unstemmed | Prolactin May Not Play a Role in Primary Antiphospholipid (Hughes') Syndrome |
| title_short | Prolactin May Not Play a Role in Primary Antiphospholipid (Hughes') Syndrome |
| title_sort | prolactin may not play a role in primary antiphospholipid hughes syndrome |
| url | http://dx.doi.org/10.1155/2011/248243 |
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