RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022)
Alzheimer’s disease (AD) is a common neurodegenerative disorder which has a catastrophic effect on the brain. It significantly affects people’s daily life, especially the population over the age of 65, with problems such as neuron death, memory loss, cognitive disorders, and cholinergic dysfunction....
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Istanbul University Press
2023-06-01
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| author | Elmas Rumeysa Yıldırım Nuray Ulusoy Güzeldemirci |
| author_facet | Elmas Rumeysa Yıldırım Nuray Ulusoy Güzeldemirci |
| author_sort | Elmas Rumeysa Yıldırım |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a common neurodegenerative disorder which has a catastrophic effect on the brain. It significantly affects people’s daily life, especially the population over the age of 65, with problems such as neuron death, memory loss, cognitive disorders, and cholinergic dysfunction. However, despite the drug development studies which have been conducted recently quite intensively, an effective drug molecule that can completely cure people or stop the stage of the disease has not been found yet, unfortunately. One of the reasons for this is the complexity of understanding of how the pathology of the disease arises. The most accepted theory for AD is the cholinergic hypothesis. Acetylcholine (ACh), an important neurotransmitter, is metabolized by two cholinesterase (ChE) enzymes named acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). With AD, ChE activity increases and thus the degradation of acetylcholine is triggered. In addition, it is understood that the peripheral anionic region (PAS) of the AChE also caused the formation of Aβ-peptide fibrils. Therefore, based on this hypothesis, the most effective approach in treatment is the use of cholinesterase inhibitors (ChEI), which try to restore ACh levels by increasing them at cholinergic synapses. Furthermore, it focused on the design of multifunctional molecules. In conclusion, considering the complex nature of the disease and its effects, it is clear that more studies are needed in this area. In this study, important and remarkable studies in recent years have been included and it aimed to contribute to future drug research andv development studies. |
| format | Article |
| id | doaj-art-e72cd02951974baaac284fbdb0a1733a |
| institution | DOAJ |
| issn | 2651-4060 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | Sabiad |
| spelling | doaj-art-e72cd02951974baaac284fbdb0a1733a2025-08-20T02:56:13ZengIstanbul University PressSabiad2651-40602023-06-016219720910.26650/JARHS2023-1197992123456RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022)Elmas Rumeysa Yıldırım0https://orcid.org/0000-0002-8261-9944Nuray Ulusoy Güzeldemirci1https://orcid.org/0000-0002-4495-4282İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeAlzheimer’s disease (AD) is a common neurodegenerative disorder which has a catastrophic effect on the brain. It significantly affects people’s daily life, especially the population over the age of 65, with problems such as neuron death, memory loss, cognitive disorders, and cholinergic dysfunction. However, despite the drug development studies which have been conducted recently quite intensively, an effective drug molecule that can completely cure people or stop the stage of the disease has not been found yet, unfortunately. One of the reasons for this is the complexity of understanding of how the pathology of the disease arises. The most accepted theory for AD is the cholinergic hypothesis. Acetylcholine (ACh), an important neurotransmitter, is metabolized by two cholinesterase (ChE) enzymes named acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). With AD, ChE activity increases and thus the degradation of acetylcholine is triggered. In addition, it is understood that the peripheral anionic region (PAS) of the AChE also caused the formation of Aβ-peptide fibrils. Therefore, based on this hypothesis, the most effective approach in treatment is the use of cholinesterase inhibitors (ChEI), which try to restore ACh levels by increasing them at cholinergic synapses. Furthermore, it focused on the design of multifunctional molecules. In conclusion, considering the complex nature of the disease and its effects, it is clear that more studies are needed in this area. In this study, important and remarkable studies in recent years have been included and it aimed to contribute to future drug research andv development studies.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/1B853B8CEB1E4A709101150DF508BF13alzheimer’s disease (ad)cholinesterase inhibitors (cheis)acetylcholinesterase inhibitors (acheis)butyrylcholinesterase inhibitors (bucheis)multifonctional drugsmulti-target directed ligands |
| spellingShingle | Elmas Rumeysa Yıldırım Nuray Ulusoy Güzeldemirci RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022) Sabiad alzheimer’s disease (ad) cholinesterase inhibitors (cheis) acetylcholinesterase inhibitors (acheis) butyrylcholinesterase inhibitors (bucheis) multifonctional drugs multi-target directed ligands |
| title | RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022) |
| title_full | RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022) |
| title_fullStr | RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022) |
| title_full_unstemmed | RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022) |
| title_short | RECENT ADVANCES OF CHOLINESTERASE INHIBITORS PLAYING A CRITICAL ROLE IN THE TREATMENT OF ALZHEIMER’S DISEASE (2020-2022) |
| title_sort | recent advances of cholinesterase inhibitors playing a critical role in the treatment of alzheimer s disease 2020 2022 |
| topic | alzheimer’s disease (ad) cholinesterase inhibitors (cheis) acetylcholinesterase inhibitors (acheis) butyrylcholinesterase inhibitors (bucheis) multifonctional drugs multi-target directed ligands |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/1B853B8CEB1E4A709101150DF508BF13 |
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