Diagnosis and Management of Chronic Nonbacterial Osteomyelitis in a Dog
This case presents the first documented successful medical management of chronic nonbacterial osteomyelitis (CNO) in a small dog—a condition rarely described in veterinary medicine. A 4-year-old castrated male Pomeranian dog weighing 4.6 kg was presented with a 3-week history of right hindlimb lamen...
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MDPI AG
2025-05-01
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| author | Young-Sun Jeong Yun-Joo Geum Hyun-Jung Han |
| author_facet | Young-Sun Jeong Yun-Joo Geum Hyun-Jung Han |
| author_sort | Young-Sun Jeong |
| collection | DOAJ |
| description | This case presents the first documented successful medical management of chronic nonbacterial osteomyelitis (CNO) in a small dog—a condition rarely described in veterinary medicine. A 4-year-old castrated male Pomeranian dog weighing 4.6 kg was presented with a 3-week history of right hindlimb lameness. Radiographic examination revealed osteolytic lesions, periosteal reactions, and decreased muscle mass in the affected limb. Microbial and blood culture tests showed negative results, whereas cytological and histopathological analyses of the right distal femur confirmed neutrophilic inflammation and osteomyelitis, leading to a diagnosis of CNO. Clinical and radiographic improvements were observed following administration of bisphosphonates, disease-modifying anti-rheumatic drugs, and glucocorticoids. This case underscores the possibility of non-infectious osteomyelitis in dogs and suggests that adapting human treatment strategies may be beneficial. Further research is needed to clarify the diagnostic criteria and pathophysiology of CNO in veterinary medicine. |
| format | Article |
| id | doaj-art-e72cbd2603494946aca46ddc277acc30 |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-e72cbd2603494946aca46ddc277acc302025-08-20T03:46:49ZengMDPI AGAnimals2076-26152025-05-011511159310.3390/ani15111593Diagnosis and Management of Chronic Nonbacterial Osteomyelitis in a DogYoung-Sun Jeong0Yun-Joo Geum1Hyun-Jung Han2Department of Veterinary Emergency and Critical Care Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Veterinary Emergency and Critical Care Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Veterinary Emergency and Critical Care Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of KoreaThis case presents the first documented successful medical management of chronic nonbacterial osteomyelitis (CNO) in a small dog—a condition rarely described in veterinary medicine. A 4-year-old castrated male Pomeranian dog weighing 4.6 kg was presented with a 3-week history of right hindlimb lameness. Radiographic examination revealed osteolytic lesions, periosteal reactions, and decreased muscle mass in the affected limb. Microbial and blood culture tests showed negative results, whereas cytological and histopathological analyses of the right distal femur confirmed neutrophilic inflammation and osteomyelitis, leading to a diagnosis of CNO. Clinical and radiographic improvements were observed following administration of bisphosphonates, disease-modifying anti-rheumatic drugs, and glucocorticoids. This case underscores the possibility of non-infectious osteomyelitis in dogs and suggests that adapting human treatment strategies may be beneficial. Further research is needed to clarify the diagnostic criteria and pathophysiology of CNO in veterinary medicine.https://www.mdpi.com/2076-2615/15/11/1593bisphosphonatescaninedisease-modifying anti-rheumatic drugs (DMARDs)glucocorticoidsnon-infectious osteomyelitis |
| spellingShingle | Young-Sun Jeong Yun-Joo Geum Hyun-Jung Han Diagnosis and Management of Chronic Nonbacterial Osteomyelitis in a Dog Animals bisphosphonates canine disease-modifying anti-rheumatic drugs (DMARDs) glucocorticoids non-infectious osteomyelitis |
| title | Diagnosis and Management of Chronic Nonbacterial Osteomyelitis in a Dog |
| title_full | Diagnosis and Management of Chronic Nonbacterial Osteomyelitis in a Dog |
| title_fullStr | Diagnosis and Management of Chronic Nonbacterial Osteomyelitis in a Dog |
| title_full_unstemmed | Diagnosis and Management of Chronic Nonbacterial Osteomyelitis in a Dog |
| title_short | Diagnosis and Management of Chronic Nonbacterial Osteomyelitis in a Dog |
| title_sort | diagnosis and management of chronic nonbacterial osteomyelitis in a dog |
| topic | bisphosphonates canine disease-modifying anti-rheumatic drugs (DMARDs) glucocorticoids non-infectious osteomyelitis |
| url | https://www.mdpi.com/2076-2615/15/11/1593 |
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