Human cytomegalovirus and neonatal infection
Human cytomegalovirus is an ancient virus that has co-evolved with humans. It establishes a life-long infection in suspectable individuals for which there is no vaccination or cure. The virus can be transmitted to a developing fetus in seropositive pregnant women, and it is the leading cause of cong...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517424000397 |
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| author | Shelley M. Lawrence |
| author_facet | Shelley M. Lawrence |
| author_sort | Shelley M. Lawrence |
| collection | DOAJ |
| description | Human cytomegalovirus is an ancient virus that has co-evolved with humans. It establishes a life-long infection in suspectable individuals for which there is no vaccination or cure. The virus can be transmitted to a developing fetus in seropositive pregnant women, and it is the leading cause of congenital infectious disease. While the majority of infected infants remain asymptomatic at birth, congenital cytomegalovirus infection can lead to substantial long-term neurodevelopmental impairments in survivors, resulting in considerable economic and social hardships. Recent discoveries regarding cytomegalovirus pathophysiology and viral replication cycles might enable the development of innovative diagnostics and therapeutics, including an effective vaccine. This Review will detail our understanding of human cytomegalovirus infection, with an in-depth discussion regarding the viral genome and transcriptome that contributes to its pathophysiology. The neonate's clinical course will also be highlighted, including maternal and neonatal testing, treatment recommendations, and long-term outcomes. |
| format | Article |
| id | doaj-art-e72ae28fcc2a43a9a2e075ff84bf6114 |
| institution | OA Journals |
| issn | 2666-5174 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-e72ae28fcc2a43a9a2e075ff84bf61142025-08-20T02:30:34ZengElsevierCurrent Research in Microbial Sciences2666-51742024-01-01710025710.1016/j.crmicr.2024.100257Human cytomegalovirus and neonatal infectionShelley M. Lawrence0Corresponding author at: Division of Neonatology, Department of Pediatrics, The University of Utah; 925 Chipeta Dr, Salt Lake City, Utah, 84108, USA.; University of Utah, College of Medicine, Department of Pediatrics, Division of Neonatology, Salt Lake City, UT, USAHuman cytomegalovirus is an ancient virus that has co-evolved with humans. It establishes a life-long infection in suspectable individuals for which there is no vaccination or cure. The virus can be transmitted to a developing fetus in seropositive pregnant women, and it is the leading cause of congenital infectious disease. While the majority of infected infants remain asymptomatic at birth, congenital cytomegalovirus infection can lead to substantial long-term neurodevelopmental impairments in survivors, resulting in considerable economic and social hardships. Recent discoveries regarding cytomegalovirus pathophysiology and viral replication cycles might enable the development of innovative diagnostics and therapeutics, including an effective vaccine. This Review will detail our understanding of human cytomegalovirus infection, with an in-depth discussion regarding the viral genome and transcriptome that contributes to its pathophysiology. The neonate's clinical course will also be highlighted, including maternal and neonatal testing, treatment recommendations, and long-term outcomes.http://www.sciencedirect.com/science/article/pii/S2666517424000397CytomegalovirusNeonatesCongenital infectionAcquired infectionIn pregnancyAntivirals |
| spellingShingle | Shelley M. Lawrence Human cytomegalovirus and neonatal infection Current Research in Microbial Sciences Cytomegalovirus Neonates Congenital infection Acquired infection In pregnancy Antivirals |
| title | Human cytomegalovirus and neonatal infection |
| title_full | Human cytomegalovirus and neonatal infection |
| title_fullStr | Human cytomegalovirus and neonatal infection |
| title_full_unstemmed | Human cytomegalovirus and neonatal infection |
| title_short | Human cytomegalovirus and neonatal infection |
| title_sort | human cytomegalovirus and neonatal infection |
| topic | Cytomegalovirus Neonates Congenital infection Acquired infection In pregnancy Antivirals |
| url | http://www.sciencedirect.com/science/article/pii/S2666517424000397 |
| work_keys_str_mv | AT shelleymlawrence humancytomegalovirusandneonatalinfection |