Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7
Conclusion: EXE can modulate the miR-30d-5p/GALNT7 axis to inhibit the expression of TSHR, thereby regulating the polarization of macrophages to the M2 phenotype and ultimately alleviating DOX-induced myocardial injury, which provides new targets and strategies for the clinical treatment of myocardi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2024/5562293 |
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| _version_ | 1849467476729921536 |
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| author | Haiyan Wu Ruoyu Zhou Hanxin Kong Jieqiong Yang Suijuan Liu Xiaolin Wei Kunzhi Li Yunmei Zhang |
| author_facet | Haiyan Wu Ruoyu Zhou Hanxin Kong Jieqiong Yang Suijuan Liu Xiaolin Wei Kunzhi Li Yunmei Zhang |
| author_sort | Haiyan Wu |
| collection | DOAJ |
| description | Conclusion: EXE can modulate the miR-30d-5p/GALNT7 axis to inhibit the expression of TSHR, thereby regulating the polarization of macrophages to the M2 phenotype and ultimately alleviating DOX-induced myocardial injury, which provides new targets and strategies for the clinical treatment of myocardial injury. |
| format | Article |
| id | doaj-art-e7296b1167534264b164cc0d41eebb87 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e7296b1167534264b164cc0d41eebb872025-08-20T03:26:11ZengWileyJournal of Immunology Research2314-71562024-01-01202410.1155/2024/5562293Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7Haiyan Wu0Ruoyu Zhou1Hanxin Kong2Jieqiong Yang3Suijuan Liu4Xiaolin Wei5Kunzhi Li6Yunmei Zhang7Faculty of Life Science and TechnologyMedical SchoolDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyFaculty of Life Science and TechnologyDepartment of CardiologyConclusion: EXE can modulate the miR-30d-5p/GALNT7 axis to inhibit the expression of TSHR, thereby regulating the polarization of macrophages to the M2 phenotype and ultimately alleviating DOX-induced myocardial injury, which provides new targets and strategies for the clinical treatment of myocardial injury.http://dx.doi.org/10.1155/2024/5562293 |
| spellingShingle | Haiyan Wu Ruoyu Zhou Hanxin Kong Jieqiong Yang Suijuan Liu Xiaolin Wei Kunzhi Li Yunmei Zhang Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7 Journal of Immunology Research |
| title | Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7 |
| title_full | Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7 |
| title_fullStr | Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7 |
| title_full_unstemmed | Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7 |
| title_short | Exercise Attenuates Doxorubicin-Induced Myocardial Injury by Inhibiting TSHR and Regulating Macrophage Polarization Through miR-30d-5p/GALNT7 |
| title_sort | exercise attenuates doxorubicin induced myocardial injury by inhibiting tshr and regulating macrophage polarization through mir 30d 5p galnt7 |
| url | http://dx.doi.org/10.1155/2024/5562293 |
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