Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerations
Abstract Objective Few reports have explored the application of urinary trypsinogen‐2 measurement in the early diagnosis of post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, and none have demonstrated the benefits of noninvasive testing. This study aimed to evaluate the clinic...
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2024-04-01
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| Online Access: | https://doi.org/10.1002/deo2.336 |
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| author | Kazuki Hama Atsushi Sofuni Ryosuke Nakatsubo Takayoshi Tsuchiya Reina Tanaka Ryosuke Tonozuka Shuntaro Mukai Kenjiro Yamamoto Akio Katanuma Takao Itoi |
| author_facet | Kazuki Hama Atsushi Sofuni Ryosuke Nakatsubo Takayoshi Tsuchiya Reina Tanaka Ryosuke Tonozuka Shuntaro Mukai Kenjiro Yamamoto Akio Katanuma Takao Itoi |
| author_sort | Kazuki Hama |
| collection | DOAJ |
| description | Abstract Objective Few reports have explored the application of urinary trypsinogen‐2 measurement in the early diagnosis of post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, and none have demonstrated the benefits of noninvasive testing. This study aimed to evaluate the clinical application of the rapid urinary trypsinogen‐2 dipstick test (Nipro, Japan) compared with serum amylase and lipase levels for the early diagnosis of post‐ERCP pancreatitis (PEP). Methods A total of 100 consecutive patients (54 men and 46 women) who were admitted and underwent ERCP at Tokyo Medical University Hospital from August 2021 to December 2021 were recruited. All patients underwent rapid urinary trypsinogen‐2 measurement using the dipstick test before and after ERCP. Measurements were taken 24 h before ERCP for pre‐ERCP and 1–4 h after ERCP for post‐ERCP. Additionally, serum amylase and lipase levels were measured at 8:00 a.m. of the day after ERCP (at least 8 h after ERCP), and their diagnostic abilities for PEP were compared and evaluated. Results PEP occurred in 5/100 patients (5%). The sensitivity, specificity, positive predictive value, and negative predictive value of the dipstick test for diagnosing PEP were 100%, 83.2%, 23.8%, and 100%, respectively. These results were comparable to the diagnostic performance of serum amylase and lipase levels at 8:00 a.m. on the day after ERCP (at least 8 h after ERCP). However, false positives must be considered. Conclusion The dipstick test may be useful in clinical practice as a noninvasive screening test for the early prediction of PEP. |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2024-04-01 |
| publisher | Wiley |
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| spelling | doaj-art-e728d49f07ef4efe85834b853f44dac82025-08-20T02:55:03ZengWileyDEN Open2692-46092024-04-0141n/an/a10.1002/deo2.336Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerationsKazuki Hama0Atsushi Sofuni1Ryosuke Nakatsubo2Takayoshi Tsuchiya3Reina Tanaka4Ryosuke Tonozuka5Shuntaro Mukai6Kenjiro Yamamoto7Akio Katanuma8Takao Itoi9Department of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanDepartment of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanCenter for Gastroenterology Teine Keijinkai Hospital Hokkaido JapanDepartment of Gastroenterology and Hepatology Tokyo Medical University Tokyo JapanAbstract Objective Few reports have explored the application of urinary trypsinogen‐2 measurement in the early diagnosis of post‐endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, and none have demonstrated the benefits of noninvasive testing. This study aimed to evaluate the clinical application of the rapid urinary trypsinogen‐2 dipstick test (Nipro, Japan) compared with serum amylase and lipase levels for the early diagnosis of post‐ERCP pancreatitis (PEP). Methods A total of 100 consecutive patients (54 men and 46 women) who were admitted and underwent ERCP at Tokyo Medical University Hospital from August 2021 to December 2021 were recruited. All patients underwent rapid urinary trypsinogen‐2 measurement using the dipstick test before and after ERCP. Measurements were taken 24 h before ERCP for pre‐ERCP and 1–4 h after ERCP for post‐ERCP. Additionally, serum amylase and lipase levels were measured at 8:00 a.m. of the day after ERCP (at least 8 h after ERCP), and their diagnostic abilities for PEP were compared and evaluated. Results PEP occurred in 5/100 patients (5%). The sensitivity, specificity, positive predictive value, and negative predictive value of the dipstick test for diagnosing PEP were 100%, 83.2%, 23.8%, and 100%, respectively. These results were comparable to the diagnostic performance of serum amylase and lipase levels at 8:00 a.m. on the day after ERCP (at least 8 h after ERCP). However, false positives must be considered. Conclusion The dipstick test may be useful in clinical practice as a noninvasive screening test for the early prediction of PEP.https://doi.org/10.1002/deo2.336diagnosisendoscopic retrograde cholangiopancreatographypost‐ERCP pancreatitisrapid urinary trypsinogen‐2 dipstick testtrypsinogen‐2 |
| spellingShingle | Kazuki Hama Atsushi Sofuni Ryosuke Nakatsubo Takayoshi Tsuchiya Reina Tanaka Ryosuke Tonozuka Shuntaro Mukai Kenjiro Yamamoto Akio Katanuma Takao Itoi Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerations DEN Open diagnosis endoscopic retrograde cholangiopancreatography post‐ERCP pancreatitis rapid urinary trypsinogen‐2 dipstick test trypsinogen‐2 |
| title | Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerations |
| title_full | Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerations |
| title_fullStr | Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerations |
| title_full_unstemmed | Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerations |
| title_short | Noninvasive rapid urinary trypsinogen‐2 dipstick test for early exclusion of post‐endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography: Clinical diagnosis and considerations |
| title_sort | noninvasive rapid urinary trypsinogen 2 dipstick test for early exclusion of post endoscopic retrograde cholangiopancreatography pancreatitis within hours after endoscopic retrograde cholangiopancreatography clinical diagnosis and considerations |
| topic | diagnosis endoscopic retrograde cholangiopancreatography post‐ERCP pancreatitis rapid urinary trypsinogen‐2 dipstick test trypsinogen‐2 |
| url | https://doi.org/10.1002/deo2.336 |
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