Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle
A theme among many pathogenic mycobacterial species affecting both humans and animals is a prolonged asymptomatic or latent period that can last years to decades. The mechanisms that favor progression to active disease are not well understood. Pathogen containment is often associated with an effecti...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.4061/2011/214384 |
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| author | Brandon L. Plattner Jesse M. Hostetter |
| author_facet | Brandon L. Plattner Jesse M. Hostetter |
| author_sort | Brandon L. Plattner |
| collection | DOAJ |
| description | A theme among many pathogenic mycobacterial species affecting both humans and animals is a prolonged asymptomatic or latent period that can last years to decades. The mechanisms that favor progression to active disease are not well understood. Pathogen containment is often associated with an effective cell-mediated or T-helper 1 immune profile. With certain pathogenic mycobacteria, such as Mycobacterium avium subspecies paratuberculosis, a shift to active clinical disease is associated with loss of T-helper 1 immunity and development of an ineffective humoral or T-helper 2 immune response. Recently γδ T cells have been shown to play a role early in mycobacterial infections and have been hypothesized to influence disease outcome. The purpose of this paper is to compare recent advancements in our understanding of γδ T cells in humans, cattle, and mice and to discuss roles of γδ T cells in host response to mycobacterial infection. |
| format | Article |
| id | doaj-art-e723cd8de0b841719d5e8215928d971e |
| institution | OA Journals |
| issn | 2042-0048 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-e723cd8de0b841719d5e8215928d971e2025-08-20T02:21:10ZengWileyVeterinary Medicine International2042-00482011-01-01201110.4061/2011/214384214384Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in CattleBrandon L. Plattner0Jesse M. Hostetter1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, N1G 2W1, CanadaDepartment of Veterinary Pathology, 2720 Veterinary Medicine Complex, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USAA theme among many pathogenic mycobacterial species affecting both humans and animals is a prolonged asymptomatic or latent period that can last years to decades. The mechanisms that favor progression to active disease are not well understood. Pathogen containment is often associated with an effective cell-mediated or T-helper 1 immune profile. With certain pathogenic mycobacteria, such as Mycobacterium avium subspecies paratuberculosis, a shift to active clinical disease is associated with loss of T-helper 1 immunity and development of an ineffective humoral or T-helper 2 immune response. Recently γδ T cells have been shown to play a role early in mycobacterial infections and have been hypothesized to influence disease outcome. The purpose of this paper is to compare recent advancements in our understanding of γδ T cells in humans, cattle, and mice and to discuss roles of γδ T cells in host response to mycobacterial infection.http://dx.doi.org/10.4061/2011/214384 |
| spellingShingle | Brandon L. Plattner Jesse M. Hostetter Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle Veterinary Medicine International |
| title | Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle |
| title_full | Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle |
| title_fullStr | Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle |
| title_full_unstemmed | Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle |
| title_short | Comparative Gamma Delta T Cell Immunology: A Focus on Mycobacterial Disease in Cattle |
| title_sort | comparative gamma delta t cell immunology a focus on mycobacterial disease in cattle |
| url | http://dx.doi.org/10.4061/2011/214384 |
| work_keys_str_mv | AT brandonlplattner comparativegammadeltatcellimmunologyafocusonmycobacterialdiseaseincattle AT jessemhostetter comparativegammadeltatcellimmunologyafocusonmycobacterialdiseaseincattle |