Research and development prospects of TRIM65
Abstract Ubiquitination, the prevalent posttranslational modification, plays a crucial role in regulating protein function, localization, and degradation within cellular environments. As an E3 ubiquitin ligase, TRIM65 has been shown in various studies to facilitate the ubiquitination of specific sub...
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| Format: | Article |
| Language: | English |
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Springer
2025-08-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-025-06285-9 |
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| _version_ | 1849226685407297536 |
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| author | Nian-Hua Deng Jie-Hai Chen Zhen Tian Shou-Bo Quan |
| author_facet | Nian-Hua Deng Jie-Hai Chen Zhen Tian Shou-Bo Quan |
| author_sort | Nian-Hua Deng |
| collection | DOAJ |
| description | Abstract Ubiquitination, the prevalent posttranslational modification, plays a crucial role in regulating protein function, localization, and degradation within cellular environments. As an E3 ubiquitin ligase, TRIM65 has been shown in various studies to facilitate the ubiquitination of specific substrates, thereby controlling inflammation, innate immune responses, cell proliferation, apoptosis, and tumor progression. Given the multifaceted and significant role of TRIM65, this review compiles existing research on TRIM65 and lays the groundwork for future studies aimed at uncovering the mechanisms of TRIM65. Further understanding of TRIM65’s interactions with its substrate proteins will offer valuable insights into the molecular underpinnings of certain diseases. Additionally, by identifying small molecules or inhibitors that target TRIM65, we may be able to develop novel drugs that modulate its activity. Such research could lead to more precise and effective treatments for conditions such as chronic inflammation, autoimmune diseases, and cancer. In summary, the study of TRIM65 not only enhances our understanding of fundamental cellular processes but also opens up new perspectives and avenues for the development of innovative therapies. |
| format | Article |
| id | doaj-art-e7222583069d4b60a5da339b0a88fe74 |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-e7222583069d4b60a5da339b0a88fe742025-08-24T11:06:18ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-08-01151811810.1007/s00432-025-06285-9Research and development prospects of TRIM65Nian-Hua Deng0Jie-Hai Chen1Zhen Tian2Shou-Bo Quan3The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical UniversityDongguan Maternal and Child Health Care HospitalThe Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical UniversityThe Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical UniversityAbstract Ubiquitination, the prevalent posttranslational modification, plays a crucial role in regulating protein function, localization, and degradation within cellular environments. As an E3 ubiquitin ligase, TRIM65 has been shown in various studies to facilitate the ubiquitination of specific substrates, thereby controlling inflammation, innate immune responses, cell proliferation, apoptosis, and tumor progression. Given the multifaceted and significant role of TRIM65, this review compiles existing research on TRIM65 and lays the groundwork for future studies aimed at uncovering the mechanisms of TRIM65. Further understanding of TRIM65’s interactions with its substrate proteins will offer valuable insights into the molecular underpinnings of certain diseases. Additionally, by identifying small molecules or inhibitors that target TRIM65, we may be able to develop novel drugs that modulate its activity. Such research could lead to more precise and effective treatments for conditions such as chronic inflammation, autoimmune diseases, and cancer. In summary, the study of TRIM65 not only enhances our understanding of fundamental cellular processes but also opens up new perspectives and avenues for the development of innovative therapies.https://doi.org/10.1007/s00432-025-06285-9UbiquitinationTRIM65InflammationCancerTargeted protein degradation |
| spellingShingle | Nian-Hua Deng Jie-Hai Chen Zhen Tian Shou-Bo Quan Research and development prospects of TRIM65 Journal of Cancer Research and Clinical Oncology Ubiquitination TRIM65 Inflammation Cancer Targeted protein degradation |
| title | Research and development prospects of TRIM65 |
| title_full | Research and development prospects of TRIM65 |
| title_fullStr | Research and development prospects of TRIM65 |
| title_full_unstemmed | Research and development prospects of TRIM65 |
| title_short | Research and development prospects of TRIM65 |
| title_sort | research and development prospects of trim65 |
| topic | Ubiquitination TRIM65 Inflammation Cancer Targeted protein degradation |
| url | https://doi.org/10.1007/s00432-025-06285-9 |
| work_keys_str_mv | AT nianhuadeng researchanddevelopmentprospectsoftrim65 AT jiehaichen researchanddevelopmentprospectsoftrim65 AT zhentian researchanddevelopmentprospectsoftrim65 AT shouboquan researchanddevelopmentprospectsoftrim65 |