Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies
The co evolution of tumor cells and microenvironmental matrix components almost determines the series of processes involved in cancer occurrence and progression. However, many anti-cancer treatments are designed around tumor cells, neglecting the supportive role of stromal cells. Cancer-associated f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1596947/full |
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| author | Chengyun Pan Chengyun Pan Chengyun Pan Lin Zheng Jishi Wang Jishi Wang Jishi Wang |
| author_facet | Chengyun Pan Chengyun Pan Chengyun Pan Lin Zheng Jishi Wang Jishi Wang Jishi Wang |
| author_sort | Chengyun Pan |
| collection | DOAJ |
| description | The co evolution of tumor cells and microenvironmental matrix components almost determines the series of processes involved in cancer occurrence and progression. However, many anti-cancer treatments are designed around tumor cells, neglecting the supportive role of stromal cells. Cancer-associated fibroblasts (CAFs), as the main stromal cells in tumor microenvironment, are currently considered as a key component promoting tumorigenesis, development, and regulating the transfer of tumor cells to distant locations through secretion of different growth factors, cytokines, chemokines, and the degradation of extracellular matrix. Therefore, the strategy of targeting both cancer cells and CAFs shows great potential in cancer treatment. In hematological malignancies, the role of CAFs in the progression of tumors has gradually been recently tapped. This review describes the role and functional characteristics of CAFs in tumors, mainly concentrates on the potential role of CAFs in the disease progression of hematological malignancies according to recent findings, and emphasizes the importance of CAFs as a key target to overcome tumor progression and improve treatment efficacy. |
| format | Article |
| id | doaj-art-e72073564e344b34bc1ff26907744cd4 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-e72073564e344b34bc1ff26907744cd42025-08-20T03:47:19ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-06-011510.3389/fonc.2025.15969471596947Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignanciesChengyun Pan0Chengyun Pan1Chengyun Pan2Lin Zheng3Jishi Wang4Jishi Wang5Jishi Wang6Department of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Hematology, Hematological Institute of Guizhou Province, Guiyang, Guizhou, ChinaKey Laboratory of Hematological Disease Diagnostic and Treatment Centre, Guizhou Province Hematopoietic Stem Cell Transplantation Centre, Guiyang, Guizhou, ChinaDepartment of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Hematology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, ChinaDepartment of Hematology, Hematological Institute of Guizhou Province, Guiyang, Guizhou, ChinaKey Laboratory of Hematological Disease Diagnostic and Treatment Centre, Guizhou Province Hematopoietic Stem Cell Transplantation Centre, Guiyang, Guizhou, ChinaThe co evolution of tumor cells and microenvironmental matrix components almost determines the series of processes involved in cancer occurrence and progression. However, many anti-cancer treatments are designed around tumor cells, neglecting the supportive role of stromal cells. Cancer-associated fibroblasts (CAFs), as the main stromal cells in tumor microenvironment, are currently considered as a key component promoting tumorigenesis, development, and regulating the transfer of tumor cells to distant locations through secretion of different growth factors, cytokines, chemokines, and the degradation of extracellular matrix. Therefore, the strategy of targeting both cancer cells and CAFs shows great potential in cancer treatment. In hematological malignancies, the role of CAFs in the progression of tumors has gradually been recently tapped. This review describes the role and functional characteristics of CAFs in tumors, mainly concentrates on the potential role of CAFs in the disease progression of hematological malignancies according to recent findings, and emphasizes the importance of CAFs as a key target to overcome tumor progression and improve treatment efficacy.https://www.frontiersin.org/articles/10.3389/fonc.2025.1596947/fullcancer associated fibroblastsmicroenvironmenttumor progressionhematological malignanciesheterogeneity |
| spellingShingle | Chengyun Pan Chengyun Pan Chengyun Pan Lin Zheng Jishi Wang Jishi Wang Jishi Wang Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies Frontiers in Oncology cancer associated fibroblasts microenvironment tumor progression hematological malignancies heterogeneity |
| title | Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies |
| title_full | Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies |
| title_fullStr | Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies |
| title_full_unstemmed | Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies |
| title_short | Cancer associated fibroblasts in tumors: focusing on solid tumors and hematological malignancies |
| title_sort | cancer associated fibroblasts in tumors focusing on solid tumors and hematological malignancies |
| topic | cancer associated fibroblasts microenvironment tumor progression hematological malignancies heterogeneity |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1596947/full |
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