ASSOCIATIONS BETWEEN CLINICAL COURSE, LEFT VENTRICULAR HYPERTROPHY SEVERITY AND ACE GENE I/D POLYMORPHISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE HEART
The manifold studies on ACE gene impact on left ventricular hypertrophy (LVH) development in hypertrophic cardiomyopathy (HCMP) and arterial hypertension (AH) have provided too contradictory results to clarify the association between ACE gene I/D polymorphism and cardiovascular pathology in these no...
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«FIRMA «SILICEA» LLC
2009-04-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1340 |
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| author | M. D. Smirnova T. V. Fofanova Z. B. Khasanova A. G. Ovchinnikov F. T. Ageev A. Yu. Postnov |
| author_facet | M. D. Smirnova T. V. Fofanova Z. B. Khasanova A. G. Ovchinnikov F. T. Ageev A. Yu. Postnov |
| author_sort | M. D. Smirnova |
| collection | DOAJ |
| description | The manifold studies on ACE gene impact on left ventricular hypertrophy (LVH) development in hypertrophic cardiomyopathy (HCMP) and arterial hypertension (AH) have provided too contradictory results to clarify the association between ACE gene I/D polymorphism and cardiovascular pathology in these nosologic forms. The study aimed to analyse the associations between clinical course, LVH severity, and ACE gene polymorphism among HCMP and AH patients. In total, 35 HCMP patients and 33 individuals with long AH duration and LVH were examined. ACE gene I/D polymorphism was studied by PCR method. Electrocardiography (ECG) and echocardiography (EchoCG) were also performed. In HCMP, ID type of ACE gene was associated with more severe ECG signs of LVH (voltage, ST-T changes), comparing to DD type. II Type was linked to greater myocardial mass, interventricular septum thickness, and left atrium dilatation, comparing to DD type. II allele was regarded as a risk allele. In AH and LVH, ACE gene ID type was associated with a tendency towards greater interventricular septum thickness, while II allele was very rare (5,4%) and linked to LVH absence. No relations to clinical course and ECG changes were observed. |
| format | Article |
| id | doaj-art-e719708b994e4a1c8ab83d764e0ce050 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2009-04-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-e719708b994e4a1c8ab83d764e0ce0502025-08-20T03:35:12Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202009-04-010265691130ASSOCIATIONS BETWEEN CLINICAL COURSE, LEFT VENTRICULAR HYPERTROPHY SEVERITY AND ACE GENE I/D POLYMORPHISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE HEARTM. D. Smirnova0T. V. Fofanova1Z. B. Khasanova2A. G. Ovchinnikov3F. T. Ageev4A. Yu. Postnov5Научно-диспансерный отдел ИКК им.А.Л. Мясникова ФГУ “РКНПК Росмедтехнологий”Научно-диспансерный отдел ИКК им.А.Л. Мясникова ФГУ “РКНПК Росмедтехнологий”Лаборатория медицинской генетики ФГУ “РКНПК Росмедтехнологий”, МоскваНаучно-диспансерный отдел ИКК им.А.Л. Мясникова ФГУ “РКНПК Росмедтехнологий”Научно-диспансерный отдел ИКК им.А.Л. Мясникова ФГУ “РКНПК Росмедтехнологий”Лаборатория медицинской генетики ФГУ “РКНПК Росмедтехнологий”, МоскваThe manifold studies on ACE gene impact on left ventricular hypertrophy (LVH) development in hypertrophic cardiomyopathy (HCMP) and arterial hypertension (AH) have provided too contradictory results to clarify the association between ACE gene I/D polymorphism and cardiovascular pathology in these nosologic forms. The study aimed to analyse the associations between clinical course, LVH severity, and ACE gene polymorphism among HCMP and AH patients. In total, 35 HCMP patients and 33 individuals with long AH duration and LVH were examined. ACE gene I/D polymorphism was studied by PCR method. Electrocardiography (ECG) and echocardiography (EchoCG) were also performed. In HCMP, ID type of ACE gene was associated with more severe ECG signs of LVH (voltage, ST-T changes), comparing to DD type. II Type was linked to greater myocardial mass, interventricular septum thickness, and left atrium dilatation, comparing to DD type. II allele was regarded as a risk allele. In AH and LVH, ACE gene ID type was associated with a tendency towards greater interventricular septum thickness, while II allele was very rare (5,4%) and linked to LVH absence. No relations to clinical course and ECG changes were observed.https://russjcardiol.elpub.ru/jour/article/view/1340hypertrophic cardiomyopathyhypertensive heartid polymorphismleft ventricular hypertrophyassociations |
| spellingShingle | M. D. Smirnova T. V. Fofanova Z. B. Khasanova A. G. Ovchinnikov F. T. Ageev A. Yu. Postnov ASSOCIATIONS BETWEEN CLINICAL COURSE, LEFT VENTRICULAR HYPERTROPHY SEVERITY AND ACE GENE I/D POLYMORPHISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE HEART Российский кардиологический журнал hypertrophic cardiomyopathy hypertensive heart id polymorphism left ventricular hypertrophy associations |
| title | ASSOCIATIONS BETWEEN CLINICAL COURSE, LEFT VENTRICULAR HYPERTROPHY SEVERITY AND ACE GENE I/D POLYMORPHISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE HEART |
| title_full | ASSOCIATIONS BETWEEN CLINICAL COURSE, LEFT VENTRICULAR HYPERTROPHY SEVERITY AND ACE GENE I/D POLYMORPHISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE HEART |
| title_fullStr | ASSOCIATIONS BETWEEN CLINICAL COURSE, LEFT VENTRICULAR HYPERTROPHY SEVERITY AND ACE GENE I/D POLYMORPHISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE HEART |
| title_full_unstemmed | ASSOCIATIONS BETWEEN CLINICAL COURSE, LEFT VENTRICULAR HYPERTROPHY SEVERITY AND ACE GENE I/D POLYMORPHISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE HEART |
| title_short | ASSOCIATIONS BETWEEN CLINICAL COURSE, LEFT VENTRICULAR HYPERTROPHY SEVERITY AND ACE GENE I/D POLYMORPHISM IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE HEART |
| title_sort | associations between clinical course left ventricular hypertrophy severity and ace gene i d polymorphism in patients with hypertrophic cardiomyopathy and hypertensive heart |
| topic | hypertrophic cardiomyopathy hypertensive heart id polymorphism left ventricular hypertrophy associations |
| url | https://russjcardiol.elpub.ru/jour/article/view/1340 |
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