EFFECT OF S-ADENOSYLMETHIONINE ON HEPATIC AND METABOLIC DISORDERS IN GUINEA PIGS WITH NONALCOHOLIC STEATOHEPATITIS

EFFECT OF S-ADENOSYLMETHIONINE ON HEPATIC AND METABOLIC DISORDERS IN GUINEA PIGS WITH NONALCOHOLIC STEATOHEPATITIS

Objective: S-adenosylmethionine (SAM) has antioxidant and anti-inflammatory actions and hepatoprotective potential. In this study, the therapeutic effectiveness of SAM was investigated in high-fat/cholesterol diet (HFCD)-induced non-alcoholic steatohepatitis (NASH).Material and Methods: In this stud...

Full description

Saved in:

Bibliographic Details
Main Authors:	İlknur Bingül, Canan Küçükgergin, Abdurrahman Fatih Aydın, Aydın Çevik, Merva Soluk Tekkeşin, Necat Vakur Olgaç, Semra Doğru Abbasoğlu, Mehmet Müjdat Uysal
Format:	Article
Language:	English
Published:	Istanbul University Press 2025-01-01
Series:	İstanbul Tıp Fakültesi Dergisi
Subjects:	s-adenosylmethionine nonalcoholic steatohepatitis high fat/cholesterol diet oxidative stress inflammatory cytokines guinea pigs
Online Access:	https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/203088A754184492BC742162E8804568
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

The efficiency of metabolic impact of S-adenosylmethionine and meldonium on parameters of lipid profile and insulin resistance during comorbid course of nonalcocholic steatohepatitis, obesity and chronic kidney disease stage І-ІІ
by: O. S. Khukhlina, et al.
Published: (2018-02-01)

VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS
by: İlknur Bingül, et al.
Published: (2021-07-01)

Clinical and pathogenetic differences of the course of flow nonalcoholic steatohepatitis in obese patients with and without hypertension
by: O.S. Khukhlina, et al.
Published: (2013-08-01)

The effectiveness of the integrated use of gepadif, ezetrol and fosinopril in the nonalcoholic steatohepatitis in patients with hypertension stage II
by: O. S. Khukhlina, et al.
Published: (2017-03-01)

CAT and CXCL8 are crucial cofactors for the progression of nonalcoholic steatohepatitis to hepatocellular carcinoma, the immune infiltration and prognosis of hepatocellular carcinoma
by: Liang Yang, et al.
Published: (2025-03-01)

Protective role of S-Adenosylmethionine against fructose-induced oxidative damage in obesity
by: Kameliya Zh Bratoeva, et al.
Published: (2017-10-01)

The impact of the ursodeoxycholic acid as monotherapy and in the combination with the lactulose on the biochemical blood tests values of the nonalcoholic steatohepatitis patients
by: I. V. Mayev, et al.
Published: (2013-03-01)

Ductular reaction in alcoholic steatohepatitis, nonalcoholic steatohepatitis and hepatitis C virus infection (immunohistochemical study)
by: O. M. Gavrilyuk
Published: (2014-04-01)

Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study
by: Chenan Liu, et al.
Published: (2024-12-01)

PREVALENCE AND RISK FACTORS ASSOCIATED WITH NON-ALCOHOLIC STEATOHEPATITIS IN PATIENTS WITH RHEUMATOID ARTHRITIS ON HYDROXYCHLOROQUINE: A POPULATION-BASED STUDY
by: Antoine BOUSTANY, et al.
Published: (2025-04-01)

Diagnostics of progression of liver fibrosis in patients with non-alcoholic steatohepatitis combined with obesity and chronic calculous cholecystitis.
by: A. Yu. Filippova
Published: (2020-04-01)

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis
by: Peiyuan Gu, et al.
Published: (2025-03-01)

Nonobese mice with nonalcoholic steatohepatitis fed on a choline‐deficient, l‐amino acid‐defined, high‐fat diet exhibit alterations in signaling pathways
by: Noriko Suzuki‐Kemuriyama, et al.
Published: (2021-11-01)

Features of the connective tissue metabolism, the content of adipokines and cytokeratin-18 in patients with non-alcoholic steatohepatitis combined with osteoarthritis and obesity
by: O. S. Khukhlina, et al.
Published: (2019-07-01)

Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis
by: Shuoyi Ma, et al.
Published: (2025-02-01)

Farnesoid X receptor (FXR) as a potential therapeutic target in nonalcoholic fatty liver disease and associated syndromes
by: Apollinariya V. Bogolyubova, et al.
Published: (2017-12-01)

Cyclooxygenase-2 and Ki67 Expression in Oral Leukoplakia: a Clinicopathological Study
by: Alper Sinanoglu, et al.
Published: (2015-06-01)

Catechins promoted Enterococcus faecalis to alleviate related indices of nonalcoholic steatohepatitis mice induced by high-fat diet
by: Ying Zhang, et al.
Published: (2025-07-01)

Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis based on network pharmacology and gut microbiota analysis in vivo and in vitro
by: Keyu Chen, et al.
Published: (2025-06-01)

Correction: Exploring the mechanisms of tetrahydrocurcumin in ameliorating nonalcoholic steatohepatitis based on network pharmacology and gut microbiota analysis in vivo and in vitro
by: Keyu Chen, et al.
Published: (2025-08-01)

Deposition features of heterovalent iron (Fe2 + and Fe3 +) in the liver in alcoholic and nonalcoholic steatohepatitis
by: V. A. Tumanskiy, et al.
Published: (2015-12-01)

Possibilities of correction of lipid-phospholipid disorders in patients with non-alcoholic steatohepatitis against obesity and pathology of the biliary tract.
by: A. Yu. Filippova
Published: (2019-11-01)

Prediction of course and progression of nonalcoholic fatty liver disease in patients with obesity and pathology of the biliary tract with the help of mathematical modeling.
by: A. Yu. Filippova, et al.
Published: (2017-12-01)

Multi‐omic network analysis identified betacellulin as a novel target of omega‐3 fatty acid attenuation of western diet‐induced nonalcoholic steatohepatitis
by: Jyothi Padiadpu, et al.
Published: (2023-10-01)

Nonalcoholic fatty liver disease: cause or consequence of insulin resistance?
by: Ekaterina E. Mishina, et al.
Published: (2017-12-01)

Non-alcoholic fatty liver disease – a rapidly growing indication for liver transplantation in the modern world
by: I. M. Iljinsky, et al.
Published: (2019-10-01)

Ileal microbial microbiome and its secondary bile acids modulate susceptibility to nonalcoholic steatohepatitis in dairy goats
by: Yue Wang, et al.
Published: (2024-11-01)

Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content
by: Haoxiang Zhu, et al.
Published: (2025-01-01)

S-adenosylmethionine metabolism shapes CD8+ T cell functions in colorectal cancer
by: Xiaohua Yang, et al.
Published: (2025-05-01)

Naringenin attenuates early hepatocarcinogenesis induced by a MASH model
by: Linda Vanessa Márquez-Quiroga, et al.
Published: (2025-07-01)

MiR-378a-3p and miR-181b-5p as nonalcoholic steatohepatitis non-invasive diagnostic biomarkers and their correlations with liver fibrosis
by: T. I. Ahmed, et al.
Published: (2024-08-01)

Features of Glucose Homeostasis and Blood Lipid Spectrum in Patients with Nonalcoholic Fatty Liver Dis ease Depending on the Obesity Degree
by: Korniichuk I., et al.
Published: (2019-04-01)

Gaps in MASLD/MASH Education: A Quantitative and Qualitative Survey with Leaders of US Graduate Medical Education Programs
by: Allen AM, et al.
Published: (2025-05-01)

Association of insulin resistance and non-alcoholic fatty liver disease
by: Ekaterina E. Mishina, et al.
Published: (2021-01-01)

Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis
by: Wei Jiang, et al.
Published: (2025-02-01)

NRF2 ACTIVATOR DIMETHYL FUMARATE DIMINISHED STEATOSIS, INFLAMMATION AND LIPID PEROXIDATION IN THE LIVER OF BINGE ETHANOL-TREATED RATS
by: İlknur Bingül, et al.
Published: (2024-01-01)

Clinical Guidelines of the Russian Society for the Study of the Liver, Russian Gastroenterological Association, Russian Society for the Prevention of Non-Communicable Diseases, Russian Association of Endocrinologists, Russian Scientific Medical Society of Therapists, National Society of Preventive Cardiology, Russian Association of Gerontologists and Geriatricians on Non-Alcoholic Fatty Liver Disease
by: V. T. Ivashkin, et al.
Published: (2025-03-01)

Global, regional, and national burden of NASH related liver cancer in adults aged 45 and above: an analysis from the GBD 2021 and forecast to 2050
by: Jianing Shi, et al.
Published: (2025-08-01)

A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing
by: Karina Benderski, et al.
Published: (2025-01-01)

Retinopathy in Metabolic Dysfunction-Associated Steatotic Liver Disease
by: Myrsini Orfanidou, et al.
Published: (2024-12-01)