Sophoridine inhibits proliferation and migration by targeting PIM1 in breast cancer

Sophoridine inhibits proliferation and migration by targeting PIM1 in breast cancer

Context Sophoridine, an alkaloid quinolizidine derived from Sophora flavescens Aiton (Fabaceae), has strong anti-tumor activity in a variety of malignancies. Nevertheless, the effects and underlying mechanism of sophoridine on breast cancer are not fully understood.Objective To identify the key targ...

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Bibliographic Details
Main Authors: Lu Chen, Yuting Xia, Liangliang Min, Yuqin Zhang, Da Huang, Yulu Zhang, Aihua You, Zhihua Li
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Pharmaceutical Biology
Subjects:
Breast cancer
Sophoridine
PIM1
ASK1/MAPK pathway
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2025.2537123
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