Ca2+ transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction

Ca2+ transfer via enhancing ER-Mito coupling contributed to BDE-47- induced hippocampal neuronal necroptosis and cognitive dysfunction

2,2,4,4-Tetrabromodiphenyl ether (BDE-47), a ubiquitous environmental pollutant, has gained increasing attention due to its high level in biological samples and potential neurotoxicity. Recent studies have indicated that the receptor interacting protein kinase 1 (RIPK1)-mediated necroptosis is impli...

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Bibliographic Details
Main Authors: Junhong Geng, Quan Yuan, Chaofang Ni, Yarong Zhang, Xiaoli Liu, Xiaoying Zhu, Xueqin Hao, Gaofeng Liang, Dongmei Wang, Hua Fan
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Ecotoxicology and Environmental Safety
Subjects:
BDE-47
ER-Mito coupling
Necroptosis
MPTP
Cognitive deficits
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325007328
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