Hypoglycemic Activity of Endophytic Extract of Senna Alata in STZ-Induced Diabetic Mice Model
Background: Senna alata belongs to the Senna family and is known to contain several bioactive constituents that contribute to its therapeutic properties. A variety of medicinal and pharmacological effects have been reported, including antidiabetic, antiasthma, anthelmintic, and antiplasmodium infect...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer – Medknow Publications
2021-07-01
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| Series: | Journal of Integrated Health Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jihs.jihs_25_21 |
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| Summary: | Background:
Senna alata belongs to the Senna family and is known to contain several bioactive constituents that contribute to its therapeutic properties. A variety of medicinal and pharmacological effects have been reported, including antidiabetic, antiasthma, anthelmintic, and antiplasmodium infection effects.
Objectives:
The goal of the study was to determine whether the extract of S. alata can reduce blood sugar levels in streptozotocin (STZ)-induced diabetic mice.
Materials and Methods:
S. alata leaves were collected from the Department of Botany, University of Nigeria Nsukka, Nigeria, authenticated, and validated. Phytochemical screening was conducted. Specifically, leaf blades were extracted in 70% ethanol for 3 min, transferred to 500 ml of water for 5 min, then cut into small pieces, and then inoculated onto malt extract agar, and local rice was used to inoculate the fermentation medium. 25 male albino mice of 30–35 g weight, average weight of 30–35 g were used in the study. Streptozotocin (STZ; 65 mg/kg) was injected intravenously to induce type 2 diabetes.
Results:
The crude extract significantly (P < 0.05) reduced the fasting blood glucose levels in STZ-induced diabetic mice. The two doses (250 and 500 mg/kg) of the ethanol extract and metformin 500 mg/kg caused a significant (P < 0.05) reduction in the fasting blood glucose levels from 0 h to the 10th h of treatment. The extract displayed a dose-related reduction in blood sugar level concerning time. The highest reduction rate was found in 500 mg/kg 409.66 ± 1.92. The fasting blood glucose reduction was dose-dependent. The highest reduction rate was found in 500 mg/kg 80.00 ± 4.00 (80.47%) being the highest dose so far. There was a reduction in the bodyweight of the animals induced with STZ.
Conclusion:
The endophytic extract of S. alata displayed useful pharmacological properties and can be used to manage diabetes and its complications. |
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| ISSN: | 2347-6486 2347-6494 |