Synergistic effect of synthetic derivatives of 1,3,4-thiadiazole with amphotericin B in antifungal therapy

Synergistic effect of synthetic derivatives of 1,3,4-thiadiazole with amphotericin B in antifungal therapy

Abstract Amphotericin B (AmB) is a potent antifungal agent with minimal resistance among clinical isolates, but its use is limited by severe side effects. Reducing its toxicity through combination therapy with synergistic compounds is a promising strategy. This study investigates the antifungal pote...

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Main Authors: Dominika Kubera, Adrianna Sławińska-Brych, Agnieszka Dróźdż, Alina Olender, Agnieszka Bogut, Arkadiusz Matwijczuk, Dariusz Karcz, Magdalena Kimsa-Dudek, Joanna Magdalena Gola, Celina Kruszniewska-Rajs, Jolanta Adamska, Magdalena Szukała, Wojciech Dąbrowski, Andrzej Stepulak, Mariusz Gagoś
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Candida
Antifungals
Combination therapy
Amphotericin B
Online Access:https://doi.org/10.1038/s41598-025-01075-2
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