Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis
Hepatocellular carcinoma with portal vein tumor thrombosis presents a significant therapeutic challenge due to its poor prognosis and limited treatment options. This review thoroughly examines diagnostic methods, including imaging techniques and classification systems such as the Japanese Vp and Che...
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| Format: | Article |
| Language: | English |
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Ewha Womans University College of Medicine
2025-01-01
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| Series: | The Ewha Medical Journal |
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| Online Access: | http://www.e-emj.org/upload/pdf/emj-48-1-12.pdf |
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| _version_ | 1849232587204067328 |
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| author | Jeayeon Park Su Jong Yu |
| author_facet | Jeayeon Park Su Jong Yu |
| author_sort | Jeayeon Park |
| collection | DOAJ |
| description | Hepatocellular carcinoma with portal vein tumor thrombosis presents a significant therapeutic challenge due to its poor prognosis and limited treatment options. This review thoroughly examines diagnostic methods, including imaging techniques and classification systems such as the Japanese Vp and Cheng’s classifications, to aid in clinical decision-making. Treatment strategies encompass liver resection and liver transplantation, particularly living donor liver transplantation after successful downstaging, which have shown potential benefits in selected cases. Locoregional therapies, including hepatic arterial infusion chemotherapy, transarterial chemoembolization, transarterial radioembolization, and external beam radiation therapy, remain vital components of treatment. Recent advancements in systemic therapies, such as sorafenib, lenvatinib, and immune checkpoint inhibitors (e.g., atezolizumab plus bevacizumab) have demonstrated improvements in overall survival and progression-free survival. These developments underscore the importance of a multidisciplinary and personalized approach to improve outcomes for patients with hepatocellular carcinoma and portal vein tumor thrombosis. |
| format | Article |
| id | doaj-art-e710a61523cb4182a33a67a08e6aa895 |
| institution | Kabale University |
| issn | 2234-2591 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Ewha Womans University College of Medicine |
| record_format | Article |
| series | The Ewha Medical Journal |
| spelling | doaj-art-e710a61523cb4182a33a67a08e6aa8952025-08-21T04:41:08ZengEwha Womans University College of MedicineThe Ewha Medical Journal2234-25912025-01-0148110.12771/emj.2025.e41587Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosisJeayeon Park0Su Jong Yu1Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, KoreaDepartment of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, KoreaHepatocellular carcinoma with portal vein tumor thrombosis presents a significant therapeutic challenge due to its poor prognosis and limited treatment options. This review thoroughly examines diagnostic methods, including imaging techniques and classification systems such as the Japanese Vp and Cheng’s classifications, to aid in clinical decision-making. Treatment strategies encompass liver resection and liver transplantation, particularly living donor liver transplantation after successful downstaging, which have shown potential benefits in selected cases. Locoregional therapies, including hepatic arterial infusion chemotherapy, transarterial chemoembolization, transarterial radioembolization, and external beam radiation therapy, remain vital components of treatment. Recent advancements in systemic therapies, such as sorafenib, lenvatinib, and immune checkpoint inhibitors (e.g., atezolizumab plus bevacizumab) have demonstrated improvements in overall survival and progression-free survival. These developments underscore the importance of a multidisciplinary and personalized approach to improve outcomes for patients with hepatocellular carcinoma and portal vein tumor thrombosis.http://www.e-emj.org/upload/pdf/emj-48-1-12.pdfhepatocellular carcinomaimmune checkpoint inhibitorsliver transplantationportal veintherapeutic chemoembolization |
| spellingShingle | Jeayeon Park Su Jong Yu Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis The Ewha Medical Journal hepatocellular carcinoma immune checkpoint inhibitors liver transplantation portal vein therapeutic chemoembolization |
| title | Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis |
| title_full | Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis |
| title_fullStr | Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis |
| title_full_unstemmed | Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis |
| title_short | Management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis |
| title_sort | management strategies for advanced hepatocellular carcinoma with portal vein tumor thrombosis |
| topic | hepatocellular carcinoma immune checkpoint inhibitors liver transplantation portal vein therapeutic chemoembolization |
| url | http://www.e-emj.org/upload/pdf/emj-48-1-12.pdf |
| work_keys_str_mv | AT jeayeonpark managementstrategiesforadvancedhepatocellularcarcinomawithportalveintumorthrombosis AT sujongyu managementstrategiesforadvancedhepatocellularcarcinomawithportalveintumorthrombosis |