Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT Study
ABSTRACT Biomarkers of kidney function, including glomerular, tubular, and fibrotic markers, have been associated with blood pressure in elderly populations and individuals with kidney and cardiovascular diseases. However, limited information is available in young adults. In this study, we compared...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | The Journal of Clinical Hypertension |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jch.14911 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850066743200841728 |
|---|---|
| author | Anja Degenaar Ruan Kruger Adriaan Jacobs Catharina M. C. Mels |
| author_facet | Anja Degenaar Ruan Kruger Adriaan Jacobs Catharina M. C. Mels |
| author_sort | Anja Degenaar |
| collection | DOAJ |
| description | ABSTRACT Biomarkers of kidney function, including glomerular, tubular, and fibrotic markers, have been associated with blood pressure in elderly populations and individuals with kidney and cardiovascular diseases. However, limited information is available in young adults. In this study, we compared levels of several kidney function biomarkers between normotensive and hypertensive young adults and explored the associations of these biomarkers with blood pressure within these groups. In this cross‐sectional assessment, twenty‐four‐hour (24‐h) blood pressure measurements of 1055 participants (mean age = 24.6 years) were used to classify hypertension as per the 2018 ESC/ESH guidelines. Biomarkers of kidney function included estimated glomerular filtration rate, urinary albumin, alpha‐1 microglobulin (uA1M), neutrophil gelatinase‐associated lipocalin (uNGAL), uromodulin (uUMOD), and the CKD273 classifier. All urinary biomarkers, except for the CKD273 classifier, were standardized for urinary creatinine (Cr). In the hypertensive group (61.0% White; 73.2% men), urinary albumin‐to‐creatinine ratio (uACR), uNGAL/Cr and uUMOD/Cr were lower than the normotensive group. In multiple regression analyses, 24‐h systolic blood pressure (SBP) (β = 0.14; p = 0.042), 24‐h diastolic blood pressure (DBP) (β = 0.14; p = 0.040), and 24‐h mean arterial pressure (MAP) (β = 0.16; p = 0.020) associated positively with uA1M/Cr in the hypertensive group, while 24‐h MAP positively associated with uACR (β = 0.17; p = 0.017). In exploratory factor analysis, positive associations of 24‐h DBP and 24‐h MAP with a factor pattern including tubular biomarkers were observed in the hypertensive group (24‐h DBP: β = 0.18; p = 0.026, 24‐h MAP: β = 0.17; p = 0.032). In the setting of hypertension, high perfusion pressure in the kidneys may play a role in the development of proximal tubule damage and promote early deterioration in kidney function in young adults. Trial Registration: ClinicalTrials.gov identifier: NCT03292094 |
| format | Article |
| id | doaj-art-e7103ee0e02842fca90fc91ff850ae97 |
| institution | DOAJ |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-e7103ee0e02842fca90fc91ff850ae972025-08-20T02:48:39ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762024-11-0126111291130010.1111/jch.14911Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT StudyAnja Degenaar0Ruan Kruger1Adriaan Jacobs2Catharina M. C. Mels3Hypertension in Africa Research Team (HART) North‐West University Potchefstroom South AfricaHypertension in Africa Research Team (HART) North‐West University Potchefstroom South AfricaHypertension in Africa Research Team (HART) North‐West University Potchefstroom South AfricaHypertension in Africa Research Team (HART) North‐West University Potchefstroom South AfricaABSTRACT Biomarkers of kidney function, including glomerular, tubular, and fibrotic markers, have been associated with blood pressure in elderly populations and individuals with kidney and cardiovascular diseases. However, limited information is available in young adults. In this study, we compared levels of several kidney function biomarkers between normotensive and hypertensive young adults and explored the associations of these biomarkers with blood pressure within these groups. In this cross‐sectional assessment, twenty‐four‐hour (24‐h) blood pressure measurements of 1055 participants (mean age = 24.6 years) were used to classify hypertension as per the 2018 ESC/ESH guidelines. Biomarkers of kidney function included estimated glomerular filtration rate, urinary albumin, alpha‐1 microglobulin (uA1M), neutrophil gelatinase‐associated lipocalin (uNGAL), uromodulin (uUMOD), and the CKD273 classifier. All urinary biomarkers, except for the CKD273 classifier, were standardized for urinary creatinine (Cr). In the hypertensive group (61.0% White; 73.2% men), urinary albumin‐to‐creatinine ratio (uACR), uNGAL/Cr and uUMOD/Cr were lower than the normotensive group. In multiple regression analyses, 24‐h systolic blood pressure (SBP) (β = 0.14; p = 0.042), 24‐h diastolic blood pressure (DBP) (β = 0.14; p = 0.040), and 24‐h mean arterial pressure (MAP) (β = 0.16; p = 0.020) associated positively with uA1M/Cr in the hypertensive group, while 24‐h MAP positively associated with uACR (β = 0.17; p = 0.017). In exploratory factor analysis, positive associations of 24‐h DBP and 24‐h MAP with a factor pattern including tubular biomarkers were observed in the hypertensive group (24‐h DBP: β = 0.18; p = 0.026, 24‐h MAP: β = 0.17; p = 0.032). In the setting of hypertension, high perfusion pressure in the kidneys may play a role in the development of proximal tubule damage and promote early deterioration in kidney function in young adults. Trial Registration: ClinicalTrials.gov identifier: NCT03292094https://doi.org/10.1111/jch.14911alpha‐1 microglobulinhypertensiontubular healthurinary biomarkersyouth |
| spellingShingle | Anja Degenaar Ruan Kruger Adriaan Jacobs Catharina M. C. Mels Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT Study The Journal of Clinical Hypertension alpha‐1 microglobulin hypertension tubular health urinary biomarkers youth |
| title | Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT Study |
| title_full | Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT Study |
| title_fullStr | Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT Study |
| title_full_unstemmed | Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT Study |
| title_short | Phenotyping Kidney Function in Young Adults With High Blood Pressure: The African‐PREDICT Study |
| title_sort | phenotyping kidney function in young adults with high blood pressure the african predict study |
| topic | alpha‐1 microglobulin hypertension tubular health urinary biomarkers youth |
| url | https://doi.org/10.1111/jch.14911 |
| work_keys_str_mv | AT anjadegenaar phenotypingkidneyfunctioninyoungadultswithhighbloodpressuretheafricanpredictstudy AT ruankruger phenotypingkidneyfunctioninyoungadultswithhighbloodpressuretheafricanpredictstudy AT adriaanjacobs phenotypingkidneyfunctioninyoungadultswithhighbloodpressuretheafricanpredictstudy AT catharinamcmels phenotypingkidneyfunctioninyoungadultswithhighbloodpressuretheafricanpredictstudy |