Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke
Stroke, characterized by sudden onset and significant mortality rates, represents a critical challenge in effectively treating neuroinflammation to improve treatment efficacy. In this context, mesenchymal stem cell (MSC)-derived exosomes have attracted significant attention in scientific research du...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-10-01
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| Series: | Brain Hemorrhages |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589238X24000305 |
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| author | Ozal Beylerli Ilgiz Gareev Huaizhang Shi Tatiana Ilyasova |
| author_facet | Ozal Beylerli Ilgiz Gareev Huaizhang Shi Tatiana Ilyasova |
| author_sort | Ozal Beylerli |
| collection | DOAJ |
| description | Stroke, characterized by sudden onset and significant mortality rates, represents a critical challenge in effectively treating neuroinflammation to improve treatment efficacy. In this context, mesenchymal stem cell (MSC)-derived exosomes have attracted significant attention in scientific research due to their diverse cellular origin, tiny size, and huge number of bioactive molecules. Recent studies have shed light on the remarkable potential of MSC-derived exosomes to not only suppress the inflammatory responses of microglia and astrocytes, but also enhance their neuroprotective functions. Moreover, these exosomes have demonstrated a remarkable ability to modulate various immune cells and inflammatory mediators, thereby exerting profound mitigating effects on neuroinflammation. Through a thorough examination of the role and underlying mechanisms of MSC-derived exosomes in mitigating neuroinflammation after stroke, this review aims to provide comprehensive information and recommendations for the development of innovative therapeutic strategies aimed at significantly improving the treatment of stroke. |
| format | Article |
| id | doaj-art-e70fbd6cb705466393e75a5bca665cd2 |
| institution | OA Journals |
| issn | 2589-238X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Brain Hemorrhages |
| spelling | doaj-art-e70fbd6cb705466393e75a5bca665cd22025-08-20T01:50:45ZengKeAi Communications Co., Ltd.Brain Hemorrhages2589-238X2024-10-015524825610.1016/j.hest.2024.04.003Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after strokeOzal Beylerli0Ilgiz Gareev1Huaizhang Shi2Tatiana Ilyasova3Central Research Laboratory, Bashkir State Medical University, Ufa, Republic of Bashkortostan, 3 Lenin Street, 450008, RussiaEducational and Scientific Institute of Neurosurgery, Peoples’ Friendship University of Russia (RUDN University), Moscow, RussiaDepartment of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; Corresponding author at: Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.Department of Internal Diseases, Bashkir State Medical University, Ufa, Republic of Bashkortostan 450008, RussiaStroke, characterized by sudden onset and significant mortality rates, represents a critical challenge in effectively treating neuroinflammation to improve treatment efficacy. In this context, mesenchymal stem cell (MSC)-derived exosomes have attracted significant attention in scientific research due to their diverse cellular origin, tiny size, and huge number of bioactive molecules. Recent studies have shed light on the remarkable potential of MSC-derived exosomes to not only suppress the inflammatory responses of microglia and astrocytes, but also enhance their neuroprotective functions. Moreover, these exosomes have demonstrated a remarkable ability to modulate various immune cells and inflammatory mediators, thereby exerting profound mitigating effects on neuroinflammation. Through a thorough examination of the role and underlying mechanisms of MSC-derived exosomes in mitigating neuroinflammation after stroke, this review aims to provide comprehensive information and recommendations for the development of innovative therapeutic strategies aimed at significantly improving the treatment of stroke.http://www.sciencedirect.com/science/article/pii/S2589238X24000305Ischemic strokeHemorrhagic strokeNeuroinflammationMesenchymal stem cellsExosomesInflammatory mediators |
| spellingShingle | Ozal Beylerli Ilgiz Gareev Huaizhang Shi Tatiana Ilyasova Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke Brain Hemorrhages Ischemic stroke Hemorrhagic stroke Neuroinflammation Mesenchymal stem cells Exosomes Inflammatory mediators |
| title | Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke |
| title_full | Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke |
| title_fullStr | Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke |
| title_full_unstemmed | Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke |
| title_short | Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke |
| title_sort | effect of mesenchymal stem cell derived exosomes on the inflammatory response after stroke |
| topic | Ischemic stroke Hemorrhagic stroke Neuroinflammation Mesenchymal stem cells Exosomes Inflammatory mediators |
| url | http://www.sciencedirect.com/science/article/pii/S2589238X24000305 |
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