Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin
Shang-Yu Lu,1,* Han-Yao Sun,1,* Yan Zhou,2 Xi Luo,3 Sheng Liu,1 Wei-Zhong Zhou,1 Hai-Bin Shi,1 Wei Yang,1 Wei Tian1 1Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Radiology, The...
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Dove Medical Press
2024-10-01
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| Series: | Journal of Hepatocellular Carcinoma |
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| author | Lu SY Sun HY Zhou Y Luo X Liu S Zhou WZ Shi HB Yang W Tian W |
| author_facet | Lu SY Sun HY Zhou Y Luo X Liu S Zhou WZ Shi HB Yang W Tian W |
| author_sort | Lu SY |
| collection | DOAJ |
| description | Shang-Yu Lu,1,* Han-Yao Sun,1,* Yan Zhou,2 Xi Luo,3 Sheng Liu,1 Wei-Zhong Zhou,1 Hai-Bin Shi,1 Wei Yang,1 Wei Tian1 1Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 3The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Yang; Wei Tian, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, 210029, People’s Republic of China, Tel +86-18705164897 ; +86-13770615508, Email youngwei1988@163.com; tianwei@jsph.org.cnPurpose: Hepatocellular carcinoma (HCC) represents a significant global health problem, requiring precise prognostic tools for optimal treatment stratification. This study aimed to develop a new risk prediction score, called AD score, based on the serum markers alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), to offer an objective and accurate preoperative assessment of HCC in patients undergoing transarterial chemoembolization (TACE).Patients and Methods: This was a retrospective study that included 295 HCC patients who were subjected to TACE (training set, n=147; testing set, n=148). Serum AFP and DCP levels were log-transformed to construct the AD score. Multivariate Cox regression analysis on cirrhosis subgroups validated the objectivity of the model. Performance comparison of established models (Child Pugh, BCLC, ALBI, Up-to-seven, Six-and-twelve, Four and seven, HAP score, mHAP-II, FAIL-T score), was assessed through time-dependent receiver operating characteristic (ROC) curves and risk stratification.Results: The AD score, incorporating lgAFP and lgDCP, demonstrated superior predictive accuracy than the existing models. Time-dependent ROC curve revealed the consistent superiority of the AD score over a 5-year period. The risk stratification into low, intermediate, and high group based on the AD score showed a significant survival difference in both training and testing set.Conclusion: For HCC patients undergoing TACE, the AD score serves as an objective and straightforward prognostic tool, enhancing predictive accuracy and showcasing its clinical utility. It demonstrates potential significance as a crucial addition to preoperative risk assessment for TACE.Keywords: hepatocellular carcinoma, transarterial chemoembolization, prognostic model, risk assessment, AD score |
| format | Article |
| id | doaj-art-e70b883ec2294daeb6bf328f863d5bba |
| institution | OA Journals |
| issn | 2253-5969 |
| language | English |
| publishDate | 2024-10-01 |
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| series | Journal of Hepatocellular Carcinoma |
| spelling | doaj-art-e70b883ec2294daeb6bf328f863d5bba2025-08-20T02:09:52ZengDove Medical PressJournal of Hepatocellular Carcinoma2253-59692024-10-01Volume 111979199296569Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy ProthrombinLu SYSun HYZhou YLuo XLiu SZhou WZShi HBYang WTian WShang-Yu Lu,1,* Han-Yao Sun,1,* Yan Zhou,2 Xi Luo,3 Sheng Liu,1 Wei-Zhong Zhou,1 Hai-Bin Shi,1 Wei Yang,1 Wei Tian1 1Department of Interventional Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China; 3The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Yang; Wei Tian, The First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Road, Nanjing, 210029, People’s Republic of China, Tel +86-18705164897 ; +86-13770615508, Email youngwei1988@163.com; tianwei@jsph.org.cnPurpose: Hepatocellular carcinoma (HCC) represents a significant global health problem, requiring precise prognostic tools for optimal treatment stratification. This study aimed to develop a new risk prediction score, called AD score, based on the serum markers alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), to offer an objective and accurate preoperative assessment of HCC in patients undergoing transarterial chemoembolization (TACE).Patients and Methods: This was a retrospective study that included 295 HCC patients who were subjected to TACE (training set, n=147; testing set, n=148). Serum AFP and DCP levels were log-transformed to construct the AD score. Multivariate Cox regression analysis on cirrhosis subgroups validated the objectivity of the model. Performance comparison of established models (Child Pugh, BCLC, ALBI, Up-to-seven, Six-and-twelve, Four and seven, HAP score, mHAP-II, FAIL-T score), was assessed through time-dependent receiver operating characteristic (ROC) curves and risk stratification.Results: The AD score, incorporating lgAFP and lgDCP, demonstrated superior predictive accuracy than the existing models. Time-dependent ROC curve revealed the consistent superiority of the AD score over a 5-year period. The risk stratification into low, intermediate, and high group based on the AD score showed a significant survival difference in both training and testing set.Conclusion: For HCC patients undergoing TACE, the AD score serves as an objective and straightforward prognostic tool, enhancing predictive accuracy and showcasing its clinical utility. It demonstrates potential significance as a crucial addition to preoperative risk assessment for TACE.Keywords: hepatocellular carcinoma, transarterial chemoembolization, prognostic model, risk assessment, AD scorehttps://www.dovepress.com/prognosis-of-patients-with-hepatocellular-carcinoma-treated-with-tace--peer-reviewed-fulltext-article-JHChepatocellular carcinomatransarterial chemoembolizationprognostic modelrisk assessmentad score |
| spellingShingle | Lu SY Sun HY Zhou Y Luo X Liu S Zhou WZ Shi HB Yang W Tian W Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin Journal of Hepatocellular Carcinoma hepatocellular carcinoma transarterial chemoembolization prognostic model risk assessment ad score |
| title | Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin |
| title_full | Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin |
| title_fullStr | Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin |
| title_full_unstemmed | Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin |
| title_short | Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin |
| title_sort | prognosis of patients with hepatocellular carcinoma treated with tace a new score combining alpha fetoprotein and des gamma carboxy prothrombin |
| topic | hepatocellular carcinoma transarterial chemoembolization prognostic model risk assessment ad score |
| url | https://www.dovepress.com/prognosis-of-patients-with-hepatocellular-carcinoma-treated-with-tace--peer-reviewed-fulltext-article-JHC |
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