Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development

Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development

Opioids, while highly effective for pain management, are among the most addictive substances, contributing significantly to the global opioid crisis. Opioid use disorder (OUD) affects millions, with synthetic opioids like fentanyl exacerbating the epidemic due to their potency and widespread illicit...

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Bibliographic Details
Main Authors: Michael Swingler, Martina Donadoni, Ellen M. Unterwald, Sanjay B. Maggirwar, Ilker K. Sariyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neuroscience
Subjects:
opioids
tolerance
dependence
opioid receptors
signaling
alternative splicing
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1597922/full
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