Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension
Abstract Erectile dysfunction (ED) shares common risk factors with cardiovascular (CV) disease, such as a sedentary lifestyle, obesity, and metabolic syndrome. However, the relationship between ED and CV risk in Vietnam remains unknown. To investigate this, we conducted a multi-center observational...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-78182-z |
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| author | Hai Nguyen Ngoc Dang Thang Viet Luong Anh Kiem Pham The Trung Le Nhan Duc Le Hung Minh Nguyen Tien Anh Hoang Binh Anh Ho |
| author_facet | Hai Nguyen Ngoc Dang Thang Viet Luong Anh Kiem Pham The Trung Le Nhan Duc Le Hung Minh Nguyen Tien Anh Hoang Binh Anh Ho |
| author_sort | Hai Nguyen Ngoc Dang |
| collection | DOAJ |
| description | Abstract Erectile dysfunction (ED) shares common risk factors with cardiovascular (CV) disease, such as a sedentary lifestyle, obesity, and metabolic syndrome. However, the relationship between ED and CV risk in Vietnam remains unknown. To investigate this, we conducted a multi-center observational study, randomly selecting 2,936 men aged 40 to 69 years in Vietnam, with 385 participants included after exclusions. The study evaluated the 10-year CV risk using the Systematic Coronary Risk Evaluation 2-Diabetes (SCORE2-Diabetes) score and assessed ED using the International Index of Erectile Function (IIEF-5) score. Results showed that men with diabetes mellitus and hypertension had significantly lower IIEF-5 scores compared to healthy individuals (18 [15–22] vs. 23 [20–24], p < 0.001). Additionally, the IIEF-5 score proved effective in identifying patients at very high CV risk, with an area under the curve (AUC) of 0.747, a cutoff point of 18.5, sensitivity of 69.6%, and specificity of 69.9%. Furthermore, we found a significant inverse correlation between SCORE2-Diabetes and IIEF-5 (ρ = -0.45 and p < 0.001). These findings establish a significant connection between ED and CV risk in men with diabetes, underscoring the need for integrated screening and management strategies to address both conditions concurrently. |
| format | Article |
| id | doaj-art-e708cea8ce4240c48224dff1e943a6a8 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e708cea8ce4240c48224dff1e943a6a82025-08-20T02:33:05ZengNature PortfolioScientific Reports2045-23222024-11-0114111310.1038/s41598-024-78182-zExploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertensionHai Nguyen Ngoc Dang0Thang Viet Luong1Anh Kiem Pham2The Trung Le3Nhan Duc Le4Hung Minh Nguyen5Tien Anh Hoang6Binh Anh Ho7The Faculty of Medicine, Duy Tan UniversityUniversity of Medicine and Pharmacy, Hue UniversityKien Giang General HospitalDa Nang HospitalDa Nang HospitalVietnam National Heart Institute, Bach Mai HospitalUniversity of Medicine and Pharmacy, Hue UniversityCardiovascular Center, Hue Central HospitalAbstract Erectile dysfunction (ED) shares common risk factors with cardiovascular (CV) disease, such as a sedentary lifestyle, obesity, and metabolic syndrome. However, the relationship between ED and CV risk in Vietnam remains unknown. To investigate this, we conducted a multi-center observational study, randomly selecting 2,936 men aged 40 to 69 years in Vietnam, with 385 participants included after exclusions. The study evaluated the 10-year CV risk using the Systematic Coronary Risk Evaluation 2-Diabetes (SCORE2-Diabetes) score and assessed ED using the International Index of Erectile Function (IIEF-5) score. Results showed that men with diabetes mellitus and hypertension had significantly lower IIEF-5 scores compared to healthy individuals (18 [15–22] vs. 23 [20–24], p < 0.001). Additionally, the IIEF-5 score proved effective in identifying patients at very high CV risk, with an area under the curve (AUC) of 0.747, a cutoff point of 18.5, sensitivity of 69.6%, and specificity of 69.9%. Furthermore, we found a significant inverse correlation between SCORE2-Diabetes and IIEF-5 (ρ = -0.45 and p < 0.001). These findings establish a significant connection between ED and CV risk in men with diabetes, underscoring the need for integrated screening and management strategies to address both conditions concurrently.https://doi.org/10.1038/s41598-024-78182-zErectile dysfunctionCardiovascular riskDiabetes mellitusHypertensionSCORE2-DiabetesIIEF-5 |
| spellingShingle | Hai Nguyen Ngoc Dang Thang Viet Luong Anh Kiem Pham The Trung Le Nhan Duc Le Hung Minh Nguyen Tien Anh Hoang Binh Anh Ho Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension Scientific Reports Erectile dysfunction Cardiovascular risk Diabetes mellitus Hypertension SCORE2-Diabetes IIEF-5 |
| title | Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension |
| title_full | Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension |
| title_fullStr | Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension |
| title_full_unstemmed | Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension |
| title_short | Exploring the bidirectional link between erectile dysfunction and 10-year cardiovascular risk in men with diabetes and hypertension |
| title_sort | exploring the bidirectional link between erectile dysfunction and 10 year cardiovascular risk in men with diabetes and hypertension |
| topic | Erectile dysfunction Cardiovascular risk Diabetes mellitus Hypertension SCORE2-Diabetes IIEF-5 |
| url | https://doi.org/10.1038/s41598-024-78182-z |
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