Reduced PLCG1 expression is associated with inferior survival for myelodysplastic syndromes

Reduced PLCG1 expression is associated with inferior survival for myelodysplastic syndromes

Abstract The PLCG1 gene, which encodes the phospholipase C γ1 isoform, is located within the commonly deleted region of the long arm of chromosome 20 (del(20q)) observed in myelodysplastic syndromes (MDS). Phospholipase C is involved in diverse physiological and pathological cellular processes throu...

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Bibliographic Details
Main Authors: Masayuki Shiseki, Mayuko Ishii, Mari Miyazaki, Satoko Osanai, Yan‐Hua Wang, Kentaro Yoshinaga, Naoki Mori, Junji Tanaka
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Cancer Medicine
Subjects:
common deleted region
del(20q)
haploinsufficiency
MDS
PLCG1
Online Access:https://doi.org/10.1002/cam4.2717
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