Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment
Widespread structural and functional alterations have been reported in the two highly prevalent mild cognitive impairment (MCI) subtypes, amnestic MCI (aMCI) and vascular MCI (VaMCI). However, the changing pattern in functional connectivity strength (FCS) remains largely unclear. The aim of the pres...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/8812490 |
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| author | Hui Li Shuai Gao Xiuqin Jia Tao Jiang Kuncheng Li |
| author_facet | Hui Li Shuai Gao Xiuqin Jia Tao Jiang Kuncheng Li |
| author_sort | Hui Li |
| collection | DOAJ |
| description | Widespread structural and functional alterations have been reported in the two highly prevalent mild cognitive impairment (MCI) subtypes, amnestic MCI (aMCI) and vascular MCI (VaMCI). However, the changing pattern in functional connectivity strength (FCS) remains largely unclear. The aim of the present study is to detect the differences of FCS and to further explore the detailed resting-state functional connectivity (FC) alterations among VaMCI subjects, aMCI subjects, and healthy controls (HC). Twenty-six aMCI subjects, 31 VaMCI participants, and 36 HC participants underwent cognitive assessments and resting-state functional MRI scans. At first, one-way ANCOVA and post hoc analysis indicated significant decreased FCS in the left middle temporal gyrus (MTG) in aMCI and VaMCI groups compared to HC, especially in the VaMCI group. Then, we selected the left MTG as a seed to further explore the detailed resting-state FC alterations among the three groups, and the results indicated that FC between the left MTG and some frontal brain regions were significantly decreased mainly in VaMCI. Finally, partial correlation analysis revealed that the FC values between the left MTG and left inferior frontal gyrus were positively correlated with the cognitive performance episodic memory and negatively related to the living status. The present study demonstrated that different FCS alterations existed in aMCI and VaMCI. These findings may provide a novel insight into the understanding of pathophysiological mechanisms underlying different MCI subtypes. |
| format | Article |
| id | doaj-art-e702d6de46974802a88300aa962eb821 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e702d6de46974802a88300aa962eb8212025-08-20T03:26:10ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/88124908812490Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive ImpairmentHui Li0Shuai Gao1Xiuqin Jia2Tao Jiang3Kuncheng Li4Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 10053, ChinaWidespread structural and functional alterations have been reported in the two highly prevalent mild cognitive impairment (MCI) subtypes, amnestic MCI (aMCI) and vascular MCI (VaMCI). However, the changing pattern in functional connectivity strength (FCS) remains largely unclear. The aim of the present study is to detect the differences of FCS and to further explore the detailed resting-state functional connectivity (FC) alterations among VaMCI subjects, aMCI subjects, and healthy controls (HC). Twenty-six aMCI subjects, 31 VaMCI participants, and 36 HC participants underwent cognitive assessments and resting-state functional MRI scans. At first, one-way ANCOVA and post hoc analysis indicated significant decreased FCS in the left middle temporal gyrus (MTG) in aMCI and VaMCI groups compared to HC, especially in the VaMCI group. Then, we selected the left MTG as a seed to further explore the detailed resting-state FC alterations among the three groups, and the results indicated that FC between the left MTG and some frontal brain regions were significantly decreased mainly in VaMCI. Finally, partial correlation analysis revealed that the FC values between the left MTG and left inferior frontal gyrus were positively correlated with the cognitive performance episodic memory and negatively related to the living status. The present study demonstrated that different FCS alterations existed in aMCI and VaMCI. These findings may provide a novel insight into the understanding of pathophysiological mechanisms underlying different MCI subtypes.http://dx.doi.org/10.1155/2021/8812490 |
| spellingShingle | Hui Li Shuai Gao Xiuqin Jia Tao Jiang Kuncheng Li Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment Neural Plasticity |
| title | Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment |
| title_full | Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment |
| title_fullStr | Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment |
| title_full_unstemmed | Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment |
| title_short | Distinctive Alterations of Functional Connectivity Strength between Vascular and Amnestic Mild Cognitive Impairment |
| title_sort | distinctive alterations of functional connectivity strength between vascular and amnestic mild cognitive impairment |
| url | http://dx.doi.org/10.1155/2021/8812490 |
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