Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1

Long non-coding RNA MIR4435-2HG modulates pancreatic cancer stem cells and chemosensitivity to gemcitabine by targeting the miR-1252-5p/STAT1

Abstract Cancer stem cells (CSCs) are key drivers of cancer progression and therapeutic resistance. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of CSC properties. The aim of this study was to investigate the role of MIR4435-2HG in regulating CSC characteristics, tumorigenesis,...

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Bibliographic Details
Main Authors: Baocheng Xie, Peishan Wu, Hongyu Liu, XiangDi Yang, Linxuan Huang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Translational Medicine
Subjects:
MIR4435-2HG
Pancreatic cancer
Cancer stem cells
Ferroptosis
Chemosensitivity
Online Access:https://doi.org/10.1186/s12967-025-06128-8
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