MINFLUX nanoscopy enhanced with high-order vortex beams
Abstract Minimal photon fluxes (MINFLUX) nanoscopy has emerged as a transformative advancement in superresolution imaging, enabling unprecedented nanoscale observations across diverse biological scenarios. In this work, we propose, for the first time, that employing high-order vortex beams can signi...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-05-01
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| Series: | Light: Science & Applications |
| Online Access: | https://doi.org/10.1038/s41377-025-01822-0 |
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| Summary: | Abstract Minimal photon fluxes (MINFLUX) nanoscopy has emerged as a transformative advancement in superresolution imaging, enabling unprecedented nanoscale observations across diverse biological scenarios. In this work, we propose, for the first time, that employing high-order vortex beams can significantly enhance the performance of MINFLUX, surpassing the limitations of the conventional MINFLUX using the first-order vortex beam. Our theoretical analysis indicates that, for standard MINFLUX, high-order vortex beams can improve the maximum localization precision by a factor corresponding to their order, which can approach a sub-nanometer scale under optimal conditions, and for raster scan MINFLUX, high-order vortex beams allow for a wider field of view while maintaining enhanced precision. These findings underscore the potential of high-order vortex beams to elevate the performance of MINFLUX, paving the way towards ultra-high resolution imaging for a broad range of applications. |
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| ISSN: | 2047-7538 |