Reproductive tract microbiome dysbiosis associated with gynecological diseases
Female health and the microbiota of the reproductive tract are closely associated. The research scope on reproductive tract microbiota extends from the vaginal to the upper reproductive tract and from infectious diseases to various benign and malignant gynecological and obstetrical diseases. The pri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1519690/full |
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| author | Qingyue Zheng Qingyue Zheng Tianshu Sun Xiaochuan Li Xiaochuan Li Lan Zhu Lan Zhu |
| author_facet | Qingyue Zheng Qingyue Zheng Tianshu Sun Xiaochuan Li Xiaochuan Li Lan Zhu Lan Zhu |
| author_sort | Qingyue Zheng |
| collection | DOAJ |
| description | Female health and the microbiota of the reproductive tract are closely associated. The research scope on reproductive tract microbiota extends from the vaginal to the upper reproductive tract and from infectious diseases to various benign and malignant gynecological and obstetrical diseases. The primary focus of this paper was to evaluate the most recent findings about the role of reproductive tract microbiota in gynecological diseases, including endometrial polyps, uterine fibroids, endometriosis, adenomyosis, endometrial hyperplasia, and endometrial carcinoma. Different stages of gynecological diseases have diverse microbiota in the female reproductive tract, and some specific bacteria may help the disease progress. For example, Fusobacterium may exacerbate endometriosis, while treatments that target microbiota, such as antibiotics, probiotics, and flora transplantation, showed some efficacy in the experiment. These findings indicate the wonderful prospect of this field. Additionally, we have discussed how microbiome research can improve our understanding of the interactions between reproductive tract microorganisms and hosts, aid in the screening and diagnosis of gynecological diseases, and direct the development of preventive and therapeutic strategies aimed at maintaining and restoring a healthy reproductive tract microbiota when combined with other technologies like transcriptome and proteome, in vitro cultured cells, and animal models. |
| format | Article |
| id | doaj-art-e6ff9ebf0ee741d3b1b7b92ce844cfb0 |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-e6ff9ebf0ee741d3b1b7b92ce844cfb02025-08-20T03:01:03ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-02-011510.3389/fcimb.2025.15196901519690Reproductive tract microbiome dysbiosis associated with gynecological diseasesQingyue Zheng0Qingyue Zheng1Tianshu Sun2Xiaochuan Li3Xiaochuan Li4Lan Zhu5Lan Zhu6National Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaClinical Biobank, Medical Research Center, National Science and Technology Key Infrastructure on Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaNational Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaNational Clinical Research Center for Obstetric & Gynecologic Diseases, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, ChinaFemale health and the microbiota of the reproductive tract are closely associated. The research scope on reproductive tract microbiota extends from the vaginal to the upper reproductive tract and from infectious diseases to various benign and malignant gynecological and obstetrical diseases. The primary focus of this paper was to evaluate the most recent findings about the role of reproductive tract microbiota in gynecological diseases, including endometrial polyps, uterine fibroids, endometriosis, adenomyosis, endometrial hyperplasia, and endometrial carcinoma. Different stages of gynecological diseases have diverse microbiota in the female reproductive tract, and some specific bacteria may help the disease progress. For example, Fusobacterium may exacerbate endometriosis, while treatments that target microbiota, such as antibiotics, probiotics, and flora transplantation, showed some efficacy in the experiment. These findings indicate the wonderful prospect of this field. Additionally, we have discussed how microbiome research can improve our understanding of the interactions between reproductive tract microorganisms and hosts, aid in the screening and diagnosis of gynecological diseases, and direct the development of preventive and therapeutic strategies aimed at maintaining and restoring a healthy reproductive tract microbiota when combined with other technologies like transcriptome and proteome, in vitro cultured cells, and animal models.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1519690/fullreproductive tractmicrobiomegynecological diseasesvaginal microbiomeendometrial microbiomeendometrial cancer |
| spellingShingle | Qingyue Zheng Qingyue Zheng Tianshu Sun Xiaochuan Li Xiaochuan Li Lan Zhu Lan Zhu Reproductive tract microbiome dysbiosis associated with gynecological diseases Frontiers in Cellular and Infection Microbiology reproductive tract microbiome gynecological diseases vaginal microbiome endometrial microbiome endometrial cancer |
| title | Reproductive tract microbiome dysbiosis associated with gynecological diseases |
| title_full | Reproductive tract microbiome dysbiosis associated with gynecological diseases |
| title_fullStr | Reproductive tract microbiome dysbiosis associated with gynecological diseases |
| title_full_unstemmed | Reproductive tract microbiome dysbiosis associated with gynecological diseases |
| title_short | Reproductive tract microbiome dysbiosis associated with gynecological diseases |
| title_sort | reproductive tract microbiome dysbiosis associated with gynecological diseases |
| topic | reproductive tract microbiome gynecological diseases vaginal microbiome endometrial microbiome endometrial cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1519690/full |
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