Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series
ABSTRACT Cryoglobulinemia (CG) encompasses disorders in which immunoglobulins precipitate at low temperatures. According to Brouet's classification, Type I CG is linked to plasma cell disorders, while mixed CG (Types II and III) is associated with autoimmune conditions, infections (notably hepa...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | eJHaem |
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| Online Access: | https://doi.org/10.1002/jha2.70029 |
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| author | Shivangini Duggal Lakshmi Vaishnavi Prasanna Kattamuri Michel Toutoungy Eder Luna Ceron Madhumita Rondla Angelica Lehker |
| author_facet | Shivangini Duggal Lakshmi Vaishnavi Prasanna Kattamuri Michel Toutoungy Eder Luna Ceron Madhumita Rondla Angelica Lehker |
| author_sort | Shivangini Duggal |
| collection | DOAJ |
| description | ABSTRACT Cryoglobulinemia (CG) encompasses disorders in which immunoglobulins precipitate at low temperatures. According to Brouet's classification, Type I CG is linked to plasma cell disorders, while mixed CG (Types II and III) is associated with autoimmune conditions, infections (notably hepatitis C virus [HCV]), and lymphoproliferative disorders. Each type presents distinct symptoms, with Type I often causing severe vasomotor symptoms and Types II and III involving systemic features like purpura, Raynaud's phenomenon, and renal involvement. This case series presents three CG cases, illustrating diverse etiologies and presentations. Case 1 discusses CG in metastatic colon cancer with Staphylococcus aureus bacteremia, highlighting infection‐triggered CG. Case 2 covers HCV‐related mixed CG, emphasizing antiviral therapy's role. Case 3 describes a CG flare after rituximab therapy, managed with steroids. These cases emphasize a multidisciplinary approach and individualized management to address CG's complexity and improve patient outcomes. Clinical Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission. |
| format | Article |
| id | doaj-art-e6ff467e37254f9bbc68e289353373b4 |
| institution | OA Journals |
| issn | 2688-6146 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj-art-e6ff467e37254f9bbc68e289353373b42025-08-20T02:24:54ZengWileyeJHaem2688-61462025-04-0162n/an/a10.1002/jha2.70029Exploring Cryoglobulinemia's Clinical Odyssey: A Case SeriesShivangini Duggal0Lakshmi Vaishnavi Prasanna Kattamuri1Michel Toutoungy2Eder Luna Ceron3Madhumita Rondla4Angelica Lehker5Department of Internal Medicine Texas Tech Health Sciences Center El Paso Texas USADepartment of Internal Medicine Texas Tech Health Sciences Center El Paso Texas USAPaul L. Foster School of Medicine Texas Tech Health Sciences Center El Paso Texas USADepartment of Internal Medicine Texas Tech Health Sciences Center El Paso Texas USADepartment of Internal Medicine Texas Tech Health Sciences Center El Paso Texas USADepartment of Internal Medicine Texas Tech Health Sciences Center El Paso Texas USAABSTRACT Cryoglobulinemia (CG) encompasses disorders in which immunoglobulins precipitate at low temperatures. According to Brouet's classification, Type I CG is linked to plasma cell disorders, while mixed CG (Types II and III) is associated with autoimmune conditions, infections (notably hepatitis C virus [HCV]), and lymphoproliferative disorders. Each type presents distinct symptoms, with Type I often causing severe vasomotor symptoms and Types II and III involving systemic features like purpura, Raynaud's phenomenon, and renal involvement. This case series presents three CG cases, illustrating diverse etiologies and presentations. Case 1 discusses CG in metastatic colon cancer with Staphylococcus aureus bacteremia, highlighting infection‐triggered CG. Case 2 covers HCV‐related mixed CG, emphasizing antiviral therapy's role. Case 3 describes a CG flare after rituximab therapy, managed with steroids. These cases emphasize a multidisciplinary approach and individualized management to address CG's complexity and improve patient outcomes. Clinical Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.https://doi.org/10.1002/jha2.70029case seriescolon cancercryoglobulinemiahepatitis Cmonoclonal gammopathy of undetermined significance |
| spellingShingle | Shivangini Duggal Lakshmi Vaishnavi Prasanna Kattamuri Michel Toutoungy Eder Luna Ceron Madhumita Rondla Angelica Lehker Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series eJHaem case series colon cancer cryoglobulinemia hepatitis C monoclonal gammopathy of undetermined significance |
| title | Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series |
| title_full | Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series |
| title_fullStr | Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series |
| title_full_unstemmed | Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series |
| title_short | Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series |
| title_sort | exploring cryoglobulinemia s clinical odyssey a case series |
| topic | case series colon cancer cryoglobulinemia hepatitis C monoclonal gammopathy of undetermined significance |
| url | https://doi.org/10.1002/jha2.70029 |
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