B cell-helping functions of gut microbial metabolites
Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR). We recently reported that the microbial metabolites sh...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2016-09-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/b-cell-helping-functions-of-gut-microbial-metabolites/ |
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| _version_ | 1850050799540895744 |
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| author | Chang H. Kim |
| author_facet | Chang H. Kim |
| author_sort | Chang H. Kim |
| collection | DOAJ |
| description | Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR). We recently reported that the microbial metabolites short-chain fatty acids (SCFAs) regulate the metabolism and gene expression in B cells to promote antibody production (Kim et al. Gut Microbial Metabolites Fuel Host Antibody Responses. Cell Host & Microbe. 2016; 20(2):202-14). The B-cell helping function of SCFAs and its implication in the host immune system are discussed in this article. |
| format | Article |
| id | doaj-art-e6fc705d73b34b6781d1b7cb0c745028 |
| institution | DOAJ |
| issn | 2311-2638 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-e6fc705d73b34b6781d1b7cb0c7450282025-08-20T02:53:21ZengShared Science Publishers OGMicrobial Cell2311-26382016-09-0131052953110.15698/mic2016.10.536B cell-helping functions of gut microbial metabolitesChang H. Kim0Laboratory of Immunology and Hematopoiesis, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, U.S.A.Commensal microflora profoundly affects the host immune system. It has long been observed that commensal bacteria enhance antibody production in the host by producing antigens for B cell receptors (BCR) and ligands for Toll-like receptors (TLR). We recently reported that the microbial metabolites short-chain fatty acids (SCFAs) regulate the metabolism and gene expression in B cells to promote antibody production (Kim et al. Gut Microbial Metabolites Fuel Host Antibody Responses. Cell Host & Microbe. 2016; 20(2):202-14). The B-cell helping function of SCFAs and its implication in the host immune system are discussed in this article.http://microbialcell.com/researcharticles/b-cell-helping-functions-of-gut-microbial-metabolites/commensal bacteriadietary fibershort-chain fatty acidsacetatepropionate butyrateB cellsantibodies immunity |
| spellingShingle | Chang H. Kim B cell-helping functions of gut microbial metabolites Microbial Cell commensal bacteria dietary fiber short-chain fatty acids acetate propionate butyrate B cells antibodies immunity |
| title | B cell-helping functions of gut microbial metabolites |
| title_full | B cell-helping functions of gut microbial metabolites |
| title_fullStr | B cell-helping functions of gut microbial metabolites |
| title_full_unstemmed | B cell-helping functions of gut microbial metabolites |
| title_short | B cell-helping functions of gut microbial metabolites |
| title_sort | b cell helping functions of gut microbial metabolites |
| topic | commensal bacteria dietary fiber short-chain fatty acids acetate propionate butyrate B cells antibodies immunity |
| url | http://microbialcell.com/researcharticles/b-cell-helping-functions-of-gut-microbial-metabolites/ |
| work_keys_str_mv | AT changhkim bcellhelpingfunctionsofgutmicrobialmetabolites |