Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients
A total of 250 males and females were recruited to participate in this cross-sectional and case-control study that aimed at measuring several biomarkers [fasting blood glucose (FBG), glycated hemoglobin (HbA1c), thyroid hormonal profile, and antithyroglobulin antibody (ATG)] in diabetic and non-dia...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2025-06-01
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| Series: | Italian Journal of Medicine |
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| Online Access: | https://www.italjmed.org/ijm/article/view/1961 |
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| author | Batool Ibrahim Aljasmmi Awadh S Alsubhi Abdulrahman Algarni Elryah I Ali Ammar Abdelmola Hussam Ali Osman Abdelrahman Mohamed Ahmed Abukanna Marwan Ismail Asaad Babker Salah Eldin Omar Hussein |
| author_facet | Batool Ibrahim Aljasmmi Awadh S Alsubhi Abdulrahman Algarni Elryah I Ali Ammar Abdelmola Hussam Ali Osman Abdelrahman Mohamed Ahmed Abukanna Marwan Ismail Asaad Babker Salah Eldin Omar Hussein |
| author_sort | Batool Ibrahim Aljasmmi |
| collection | DOAJ |
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A total of 250 males and females were recruited to participate in this cross-sectional and case-control study that aimed at measuring several biomarkers [fasting blood glucose (FBG), glycated hemoglobin (HbA1c), thyroid hormonal profile, and antithyroglobulin antibody (ATG)] in diabetic and non-diabetic patients and comparing circulating markers of diabetes mellitus with elevated serum ATG levels in type II diabetes patients who used various analyzers. The assays were performed on Roche COBAS C311, COBAS e 411/601, and Beckman Coulter (DXC 700 AU) analyzers. The mean and standard deviation were calculated, and the independent t-test and one-way analysis of variance were used for comparison. Linear regression was conducted to assess correlations. A p-value of <0.05 was considered statistically significant. This study included 125 diabetic patients compared with 125 healthy males and females, with ages ranging from 20 to 81 years and a duration of diabetes mellitus between 4 to 15 years. The results demonstrated a significant difference in FBG, HbA1c, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and ATG levels between the diabetic patients and the healthy individuals, compared to age, gender, and duration of the disease. A moderate positive correlation was observed between FBG and HbA1c, as well as between FT3 and FT4; a negative correlation was found between FBG and HbA1c levels and TSH levels. A significant positive correlation between ATG and serum TSH levels observed in patients with type 2 diabetes mellitus indicated a strong relationship between thyroid dysfunction and diabetes, compared to the age and duration of the disease.
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| format | Article |
| id | doaj-art-e6faf5a4782c49b4bf75568f4ead0d19 |
| institution | OA Journals |
| issn | 1877-9344 1877-9352 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Italian Journal of Medicine |
| spelling | doaj-art-e6faf5a4782c49b4bf75568f4ead0d192025-08-20T02:08:00ZengPAGEPress PublicationsItalian Journal of Medicine1877-93441877-93522025-06-0110.4081/itjm.2025.1961Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patientsBatool Ibrahim Aljasmmi0Awadh S Alsubhi1Abdulrahman Algarni2Elryah I Ali3Ammar Abdelmola4Hussam Ali Osman5Abdelrahman Mohamed Ahmed Abukanna6Marwan Ismail7https://orcid.org/0000-0001-5692-1632Asaad Babker8https://orcid.org/0000-0002-5022-5676Salah Eldin Omar Hussein9https://orcid.org/0000-0002-1819-5948Medical Laboratory Sciences Department, College of Health Sciences, Gulf Medical University, AjmanClinical Laboratory Sciences, College of Applied Medical Sciences, Taibah University, Al-Madina El MonawaraDepartment of Medical Laboratory Technology, College of Applied Medical Sciences, Northern Border University, ArarDepartment of Medical Laboratory Technology, College of Applied Medical Sciences, Northern Border University, ArarDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jazan UniversityFaculty of Medical and Health Sciences, Liwa College, Abu DhabiDepartment of Medicine, College of Medicine, Northern Border University, ArarMedical Laboratory Sciences Department, College of Health Sciences, Gulf Medical University, AjmanMedical Laboratory Sciences Department, College of Health Sciences, Gulf Medical University, AjmanMedical Laboratory Sciences Department, College of Health Sciences, Gulf Medical University, Ajman A total of 250 males and females were recruited to participate in this cross-sectional and case-control study that aimed at measuring several biomarkers [fasting blood glucose (FBG), glycated hemoglobin (HbA1c), thyroid hormonal profile, and antithyroglobulin antibody (ATG)] in diabetic and non-diabetic patients and comparing circulating markers of diabetes mellitus with elevated serum ATG levels in type II diabetes patients who used various analyzers. The assays were performed on Roche COBAS C311, COBAS e 411/601, and Beckman Coulter (DXC 700 AU) analyzers. The mean and standard deviation were calculated, and the independent t-test and one-way analysis of variance were used for comparison. Linear regression was conducted to assess correlations. A p-value of <0.05 was considered statistically significant. This study included 125 diabetic patients compared with 125 healthy males and females, with ages ranging from 20 to 81 years and a duration of diabetes mellitus between 4 to 15 years. The results demonstrated a significant difference in FBG, HbA1c, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), and ATG levels between the diabetic patients and the healthy individuals, compared to age, gender, and duration of the disease. A moderate positive correlation was observed between FBG and HbA1c, as well as between FT3 and FT4; a negative correlation was found between FBG and HbA1c levels and TSH levels. A significant positive correlation between ATG and serum TSH levels observed in patients with type 2 diabetes mellitus indicated a strong relationship between thyroid dysfunction and diabetes, compared to the age and duration of the disease. https://www.italjmed.org/ijm/article/view/1961Hyperthyroidismdiabetes mellitusantithyroglobulin antibodyT2DM |
| spellingShingle | Batool Ibrahim Aljasmmi Awadh S Alsubhi Abdulrahman Algarni Elryah I Ali Ammar Abdelmola Hussam Ali Osman Abdelrahman Mohamed Ahmed Abukanna Marwan Ismail Asaad Babker Salah Eldin Omar Hussein Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients Italian Journal of Medicine Hyperthyroidism diabetes mellitus antithyroglobulin antibody T2DM |
| title | Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients |
| title_full | Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients |
| title_fullStr | Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients |
| title_full_unstemmed | Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients |
| title_short | Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients |
| title_sort | correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients |
| topic | Hyperthyroidism diabetes mellitus antithyroglobulin antibody T2DM |
| url | https://www.italjmed.org/ijm/article/view/1961 |
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