Promises of targeted therapy for low grade gliomas in children
Low grade gliomas are the most common brain tumors in children. Total resection for operable lesion helps to achieve local and system control. Nevertheless, for inaccessible tumors are required more effective treatment both to overcome the refractory course of the disease, and to mi nimize toxicity...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-07-01
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| Series: | Успехи молекулярной онкологии |
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| Online Access: | https://umo.abvpress.ru/jour/article/view/216 |
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| author | E. F. Valiakhmetova L. A. Yasko L. I. Papusha A. E. Druy A. I. Karachunsky |
| author_facet | E. F. Valiakhmetova L. A. Yasko L. I. Papusha A. E. Druy A. I. Karachunsky |
| author_sort | E. F. Valiakhmetova |
| collection | DOAJ |
| description | Low grade gliomas are the most common brain tumors in children. Total resection for operable lesion helps to achieve local and system control. Nevertheless, for inaccessible tumors are required more effective treatment both to overcome the refractory course of the disease, and to mi nimize toxicity with conventional adjuvant chemotherapy and various types of radiation therapy. In recent years, there has been an accelerated understanding of the molecular pathogenesis of some tumors in children, including low grade gliomas. Given the fact that the basis of the molecular pathogenesis of the low grade gliomas is the activation of signaling pathways MARK (mitogen activated protein kinase) and mTOR (mammalian target of rapamycin), the most promising targeted agents are BRAF, MEK and mTOR inhibitors. Nevertheless, a number of other agents have been studied to find promising targeted therapy for this tumors type. This article summarizes the latest literature evaluating new drugs in low grade glioma. |
| format | Article |
| id | doaj-art-e6fae0a208404fa4b979278f2b3c1205 |
| institution | DOAJ |
| issn | 2313-805X 2413-3787 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Успехи молекулярной онкологии |
| spelling | doaj-art-e6fae0a208404fa4b979278f2b3c12052025-08-20T03:22:00ZrusABV-pressУспехи молекулярной онкологии2313-805X2413-37872019-07-0162284110.17650/2313-805X-2019-6-2-28-41160Promises of targeted therapy for low grade gliomas in childrenE. F. Valiakhmetova0L. A. Yasko1L. I. Papusha2A. E. Druy3A. I. Karachunsky4N.N. Burdenko National Scientific and Practical Center for Neurosurgery , Ministry of Health of RussiaDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and ImmunologyDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology; N.I. Pirogov Russian National Research Medical UniversityLow grade gliomas are the most common brain tumors in children. Total resection for operable lesion helps to achieve local and system control. Nevertheless, for inaccessible tumors are required more effective treatment both to overcome the refractory course of the disease, and to mi nimize toxicity with conventional adjuvant chemotherapy and various types of radiation therapy. In recent years, there has been an accelerated understanding of the molecular pathogenesis of some tumors in children, including low grade gliomas. Given the fact that the basis of the molecular pathogenesis of the low grade gliomas is the activation of signaling pathways MARK (mitogen activated protein kinase) and mTOR (mammalian target of rapamycin), the most promising targeted agents are BRAF, MEK and mTOR inhibitors. Nevertheless, a number of other agents have been studied to find promising targeted therapy for this tumors type. This article summarizes the latest literature evaluating new drugs in low grade glioma.https://umo.abvpress.ru/jour/article/view/216low grade gliomastargeted therapybraf:kiaa1549 fusionbrafv600 mutationsubependymal giant cell astrocytomamtortyrosine kinase inhibitor |
| spellingShingle | E. F. Valiakhmetova L. A. Yasko L. I. Papusha A. E. Druy A. I. Karachunsky Promises of targeted therapy for low grade gliomas in children Успехи молекулярной онкологии low grade gliomas targeted therapy braf:kiaa1549 fusion brafv600 mutation subependymal giant cell astrocytoma mtor tyrosine kinase inhibitor |
| title | Promises of targeted therapy for low grade gliomas in children |
| title_full | Promises of targeted therapy for low grade gliomas in children |
| title_fullStr | Promises of targeted therapy for low grade gliomas in children |
| title_full_unstemmed | Promises of targeted therapy for low grade gliomas in children |
| title_short | Promises of targeted therapy for low grade gliomas in children |
| title_sort | promises of targeted therapy for low grade gliomas in children |
| topic | low grade gliomas targeted therapy braf:kiaa1549 fusion brafv600 mutation subependymal giant cell astrocytoma mtor tyrosine kinase inhibitor |
| url | https://umo.abvpress.ru/jour/article/view/216 |
| work_keys_str_mv | AT efvaliakhmetova promisesoftargetedtherapyforlowgradegliomasinchildren AT layasko promisesoftargetedtherapyforlowgradegliomasinchildren AT lipapusha promisesoftargetedtherapyforlowgradegliomasinchildren AT aedruy promisesoftargetedtherapyforlowgradegliomasinchildren AT aikarachunsky promisesoftargetedtherapyforlowgradegliomasinchildren |