Licorice extract and carbenoxolone protect PC12 cells against serum/glucose deprivation-induced apoptosis through modulation of caspase-3 and PARP activation

Licorice extract and carbenoxolone protect PC12 cells against serum/glucose deprivation-induced apoptosis through modulation of caspase-3 and PARP activation

Objective: Serum/glucose deprivation in cultured PC12 cells is considered an appropriate model for investigating detailed mechanisms of ischemia-induced brain injury. Here, we aimed to study the anti-apoptotic effects of licorice (Glycyrrhiza glabra L.) root extract and carbenoxolone on PC12 cells c...

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Bibliographic Details
Main Authors: Hossein Hosseinzadeh, Elham Ramazani, Soheyla Bakhshi, Zahra Tayarani Najjaran
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2025-07-01
Series:Avicenna Journal of Phytomedicine
Subjects:
licorice extract
carbenoxolone
apoptosis
ischemia
pc12 cells
Online Access:https://ajp.mums.ac.ir/article_25252_88e871836e1c45f0a35cd181990e2a28.pdf
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