GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway

GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway

Abstract Background Ovarian cancer (OC) progression is one of the commonest cause of female cancer death. While treatments in clinic includes primary surgery and targeted chemotherapy, curative and survival trends in OC have not significantly improved. Thus, further investigation of the mechanisms r...

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Bibliographic Details
Main Authors: Chao Tang, Lin Li, Chongying Zhu, Qiang Xu, Zihao An, Shouying Xu, Chao Lin
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
GPR137
RAB8A
Hedgehog
Ovarian cancer
Online Access:https://doi.org/10.1186/s13046-025-03275-0
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