Carnosic Acid Directly Targets STING C‐Terminal Tail to Improve STING‐Mediated Inflammatory Diseases

Carnosic Acid Directly Targets STING C‐Terminal Tail to Improve STING‐Mediated Inflammatory Diseases

Abstract cGAS (cyclic GMP‐AMP synthase)‐STING (stimulator of interferon genes) signaling plays a vital role in innate immunity, while its deregulation may lead to a wide variety of autoinflammatory and autoimmune diseases. It is essential to identify specifically effective lead compounds to inhibit...

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Main Authors: Wenqing Mu, Guang Xu, Ling Li, Jincai Wen, Ye Xiu, Jia Zhao, Tingting Liu, Ziying Wei, Wei Luo, Huijie Yang, Zhixin Wu, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
carnosic acid
cGAS‐STING
inflammatory responses
STING inhibitors
Trex1 deficiency
Online Access:https://doi.org/10.1002/advs.202417686
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