Effects of arabinoxylan on BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex and intestinal microbiome in post-stroke depressed rats

Effects of arabinoxylan on BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex and intestinal microbiome in post-stroke depressed rats

Abstract Aim To explore the effects of arabinoxylan on the BDNF/TrkB/p-CREB signaling pathway in the prefrontal cortex of post-stroke depressed rats, and to explore its neuronal protective effects through the microbial-gut-brain axis in the regulation of this pathway. Methods The rat model of post-s...

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Bibliographic Details
Main Authors: Bin-yu Bi, Lin Lin, Liu Huang, Jun Zhou, Wei-juan Yan, Ling Huang, Jie Wang, Xue-bin Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Neuroscience
Subjects:
Post-stroke depression
Arabinoxylan
BDNF/TrkB/p-CREB signaling pathway
Gut microbes
Monoamine neurotransmitters
Behavior
Online Access:https://doi.org/10.1186/s12868-025-00964-6
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