Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation
Sepsis, a life-threatening systemic inflammatory response to infection, progresses to multiorgan dysfunction involving the heart, lungs, kidneys, brain, and liver. Its heterogeneous pathogenesis involves intertwined pathways such as inflammationmetabolism imbalance, immune dysregulation, mitochondr...
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| Language: | English |
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Elsevier
2025-09-01
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| Series: | Pharmacological Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825003421 |
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| author | Zhixin Xu Jingdi Zhang Zhan Li Hongzheng Wu Honglin Xu Ye Guo Yongzhe Li |
| author_facet | Zhixin Xu Jingdi Zhang Zhan Li Hongzheng Wu Honglin Xu Ye Guo Yongzhe Li |
| author_sort | Zhixin Xu |
| collection | DOAJ |
| description | Sepsis, a life-threatening systemic inflammatory response to infection, progresses to multiorgan dysfunction involving the heart, lungs, kidneys, brain, and liver. Its heterogeneous pathogenesis involves intertwined pathways such as inflammationmetabolism imbalance, immune dysregulation, mitochondrial dysfunction, and programmed cell death. While traditional biomarkers such as CRP and PCT lack organ-specific sensitivity, emerging multiomics technologies enable systematic network analysis beyond single-molecule detection. Current organ-specific biomarkers focus on four categories: ① inflammatory factors, such as interleukin-6 and high-mobility group protein B1; ② lipid metabolism molecules, such as fatty acid-binding proteins; ③ functional enzymes, such as cholinesterase and NADPH oxidase 4; and ④ noncoding RNAs, such as miR-155 and lncRNA NEAT1, that regulate epigenetic mechanisms. This study systematically reviews the characteristics of biomarkers of organs affected by sepsis reported over the past decade, focuses on analyzing their clinical transformation potential and limitations, and explores the development strategy of multidimensional biomarkers on the basis of the organ interaction network. |
| format | Article |
| id | doaj-art-e6f2442b6f8445599902ccb96b3f49ce |
| institution | Kabale University |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-e6f2442b6f8445599902ccb96b3f49ce2025-08-22T04:55:11ZengElsevierPharmacological Research1096-11862025-09-0121910791710.1016/j.phrs.2025.107917Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulationZhixin Xu0Jingdi Zhang1Zhan Li2Hongzheng Wu3Honglin Xu4Ye Guo5Yongzhe Li6Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaCorrespondence to: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, 1Shuaifuyuan, Dongcheng District, Beijing 100730, China.; Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaCorrespondence to: Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, 1Shuaifuyuan, Dongcheng District, Beijing 100730, China.; Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, ChinaSepsis, a life-threatening systemic inflammatory response to infection, progresses to multiorgan dysfunction involving the heart, lungs, kidneys, brain, and liver. Its heterogeneous pathogenesis involves intertwined pathways such as inflammationmetabolism imbalance, immune dysregulation, mitochondrial dysfunction, and programmed cell death. While traditional biomarkers such as CRP and PCT lack organ-specific sensitivity, emerging multiomics technologies enable systematic network analysis beyond single-molecule detection. Current organ-specific biomarkers focus on four categories: ① inflammatory factors, such as interleukin-6 and high-mobility group protein B1; ② lipid metabolism molecules, such as fatty acid-binding proteins; ③ functional enzymes, such as cholinesterase and NADPH oxidase 4; and ④ noncoding RNAs, such as miR-155 and lncRNA NEAT1, that regulate epigenetic mechanisms. This study systematically reviews the characteristics of biomarkers of organs affected by sepsis reported over the past decade, focuses on analyzing their clinical transformation potential and limitations, and explores the development strategy of multidimensional biomarkers on the basis of the organ interaction network.http://www.sciencedirect.com/science/article/pii/S1043661825003421SepsisInflammation–metabolism imbalanceLipid metabolismMultiomics |
| spellingShingle | Zhixin Xu Jingdi Zhang Zhan Li Hongzheng Wu Honglin Xu Ye Guo Yongzhe Li Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation Pharmacological Research Sepsis Inflammation–metabolism imbalance Lipid metabolism Multiomics |
| title | Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation |
| title_full | Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation |
| title_fullStr | Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation |
| title_full_unstemmed | Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation |
| title_short | Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation |
| title_sort | organ targeted biomarkers of sepsis a systematic review reveals the value of inflammation and lipid metabolic dysregulation |
| topic | Sepsis Inflammation–metabolism imbalance Lipid metabolism Multiomics |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825003421 |
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