TIPE3 promotes drug resistance in colorectal cancer by enhancing autophagy via the USP19/Beclin1 pathway

TIPE3 promotes drug resistance in colorectal cancer by enhancing autophagy via the USP19/Beclin1 pathway

Abstract Drug resistance is a major obstacle to the effective treatment of colorectal cancer (CRC). However, the underlying mechanism remains unclear. In this study, we investigated the function and mechanism of TIPE3 in drug resistance of CRC. TIPE3 expression in clinical samples and CRC cell lines...

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Bibliographic Details
Main Authors:	Chun Chen, Longyang Jin, Hong Wan, Hu Liu, Shuping Zhang, Gang Shen, Jiao Gong, Yong Zhu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2025-04-01
Series:	Cell Death Discovery
Online Access:	https://doi.org/10.1038/s41420-025-02477-x
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