Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch.

Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch.

Pyruvate is situated at the intersection of oxidative phosphorylation (OXPHOS) and glycolysis, which are the primary energy-producing pathways in cells. Cancer therapies targeting these pathways have been previously documented, indicating that inhibiting one pathway may lead to functional compensati...

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Main Authors: Yuki Aisu, Nobu Oshima, Fuminori Hyodo, Abdelazim Elsayed Elhelaly, Akihiko Masuo, Tomoaki Okada, Shigeo Hisamori, Shigeru Tsunoda, Koya Hida, Tomonori Morimoto, Hiroyuki Miyoshi, Makoto M Taketo, Masayuki Matsuo, Leonard M Neckers, Yoshiharu Sakai, Kazutaka Obama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0309700
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